| Type | Description |
|---|---|
| Definition | exonuclease 3'-5' domain containing 2 |
| Date | Results | Publications |
|---|---|---|
| 2020-01-18 11:48:00 | EXD2 deficiency leads to fork collapse, hypersensitivity to replication inhibitors, and genomic instability. Impeding fork regression by inactivation of SMARCAL1 or removal of RECQ1's inhibition in EXD2(-/-) cells restores efficient fork restart and genome stability. Moreover, purified EXD2 efficiently processes substrates mimicking regressed forks. | 31255466 |
| 2020-01-11 10:46:00 | EXD2 is anchored to the mitochondrial outer membrane through a conserved N-terminal transmembrane domain, while the C-terminal region is cytosolic. Crystal structures of the exonuclease domain in complex with Mn2+/Mg2+ revealed a domain-swapped dimer in which the central alpha5-alpha7 helices are mutually crossed over, resulting in chimeric active sites. | 31127291 |
| 2019-10-05 12:43:00 | EXD2 re-locates to the nucleus following double-strand breaks and thus is unlikely to have a direct role in nuclear DNA repair. Knockdown or overexpression of EXD2 affects the cellular distribution of mitochondria. | 29599527 |
| 2016-08-13 10:22:00 | establish that EXD2 stimulates both short- and long-range DSB resection | 26807646 |
| Type | IDs |
|---|---|
| Synonymous | C14orf114, EXDL2 |
| Gene |
UniProtKB-ID:
EXD2_HUMAN,
A8K948_HUMAN,
Q86TX3_HUMAN
UniprotKB:
Q9NVH0,
A8K948,
Q86TX3
UniParc:
UPI0000577ED7,
UPI00015DA91F,
UPI00000718B4,
UPI000000CC47
EMBL:
BX647767,
AK001600,
AK295601,
AL834434,
CH471061,
AL359317,
BX161412,
BC001962,
AK292563
Ensembl:
ENSG00000081177
KO:
hsa:55218
|
| Nucleutide sequences |
EMBL-CDS:
EAW80985.1,
BAG58488.1,
AAH01962.1,
CAD39094.2,
BAA91781.1,
CAH10568.1,
BAF85252.1,
CAD61888.1
Ensembl_TRS:
ENST00000409018,
ENST00000409675,
ENST00000409014,
ENST00000409949,
ENST00000312994,
ENST00000409242
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000387331,
ENSP00000386839,
ENSP00000386915,
ENSP00000386632,
ENSP00000386762,
ENSP00000313140
RefSeq:
NP_060669.1,
NP_001180290.1,
NP_001180289.1,
XP_016876910.1,
NP_001180291.1,
XP_011535210.1,
XP_005267874.1,
NP_001180292.1
|
| Others |
UniRef100:
UniRef100_A8K948,
UniRef100_Q86TX3,
UniRef100_Q9NVH0
UniRef90:
UniRef90_A0A250Y241,
UniRef90_Q86TX3,
UniRef90_Q9NVH0
UniRef50:
UniRef50_Q86TX3,
UniRef50_C3Z1Z1,
UniRef50_Q9NVH0
UniGene:
Hs.533878
CCDS:
CCDS9793.1,
CCDS53902.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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