| Type | Description |
|---|---|
| Definition | adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:33:00 | The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic beta-cells. | 33122440 |
| 2019-05-04 12:06:00 | A negative correlation of expression is evident between APPL2 and OCC-1 genes in breast cancer specimen. Unlike OCC-1A/B which encodes a small protein, OCC-1D noncoding RNA overexpression lead to APPL2 downregulation in MCF7 cells. | 30218350 |
| 2017-09-09 10:24:00 | Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 gene provides a putative colorectal neoplasm progression index. | 27986894 |
| 2016-11-05 10:22:00 | Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines. | 26583432 |
| 2015-05-23 11:28:00 | ATM is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair. | 24763056 |
| Type | IDs |
|---|---|
| Synonymous | DIP13B |
| Gene |
UniProtKB-ID:
DP13B_HUMAN
UniprotKB:
Q8NEU8
UniParc:
UPI00020CE3BC,
UPI000006D221,
UPI0002065724
EMBL:
AK297100,
BC033731,
AC016257,
AC078874,
AY113704,
AK001521,
AK296610
Ensembl:
ENSG00000136044
KO:
hsa:55198
|
| Nucleutide sequences |
EMBL-CDS:
BAH12496.1,
AAH33731.1,
BAH12397.1,
AAM55530.1
Ensembl_TRS:
ENST00000258530,
ENST00000539978,
ENST00000551662
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000444472,
ENSP00000446917,
ENSP00000258530
RefSeq:
NP_001238834.1,
XP_016875043.1,
XP_016875040.1,
XP_011536834.1,
XP_011536832.1,
XP_016875042.1,
XP_011536833.1,
NP_001238833.1,
XP_016875041.1,
XP_006719535.1,
NP_060641.2
|
| Others |
UniRef100:
UniRef100_Q8NEU8
UniRef90:
UniRef90_Q8NEU8
UniRef50:
UniRef50_Q8NEU8
UniGene:
Hs.506603
CCDS:
CCDS58276.1,
CCDS9101.1,
CCDS58275.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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