| Type | Description |
|---|---|
| Definition | regulation of nuclear pre-mRNA domain containing 1A |
| Date | Results | Publications |
|---|---|---|
| 2019-12-14 10:44:00 | The Wnt/beta-catenin signaling antagonist RPRD1A was downregulated and its upstream regulator miR-454-3p was amplified and overexpressed in metastatic breast cancer, and both were correlated with overall and relapse-free survival in breast cancer patients. | 30809286 |
| 2015-06-27 11:20:00 | Data suggest that p15RS (p15INK4b-related sequence) acts as an intrinsic transcriptional repressor for Wnt/beta-catenin-mediated gene transcription through recruiting HDAC2 histone deacetylase. | 25697359 |
| 2014-10-11 10:50:00 | RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2. | 24997600 |
| 2012-09-29 11:03:00 | The p15RS expression specifically downregulates the expression of cathepsin B and MMP-9 at RNA levels, which are known to promote cell invasion through degrading extracellular matrix proteins. | 22580456 |
| 2010-12-04 10:04:00 | p15RS inhibits Wnt signaling by interrupting beta-catenin.TCF4 complex formation and that Wnt signaling initiates downstream gene expression by removing p15RS from promoters. | 20739273 |
| Type | IDs |
|---|---|
| Synonymous | HsT3101, P15RS |
| Gene |
UniProtKB-ID:
RPR1A_HUMAN,
A0A024RC37_HUMAN,
A0A0C4DGQ6_HUMAN
UniprotKB:
Q96P16,
A0A024RC37,
A0A0C4DGQ6
UniParc:
UPI000013E641,
UPI000007048C,
UPI0000036029
EMBL:
BC010136,
CH471088,
AK314569,
AC091060,
BC000225,
AK292907,
AF419845,
AK001518
Ensembl:
ENSG00000141425
KO:
hsa:55197
|
| Nucleutide sequences |
EMBL-CDS:
EAX01367.1,
BAG37150.1,
BAA91736.1,
BAF85596.1,
EAX01366.1,
AAL15972.1,
EAX01365.1,
AAH00225.2,
AAH10136.1,
EAX01369.1,
EAX01368.1
Gene_ORFName:
hCG_24843
Ensembl_TRS:
ENST00000399022,
ENST00000357384,
ENST00000590898,
ENST00000588737,
ENST00000589050
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000381984,
ENSP00000467991,
ENSP00000465444,
ENSP00000349955,
ENSP00000468209
RefSeq:
XP_011524350.1,
NP_001290340.1,
NP_001290342.1,
XP_011524351.1,
NP_060640.2,
NP_001290341.1,
XP_011524352.1,
XP_016881297.1
|
| Others |
UniRef100:
UniRef100_Q96P16,
UniRef100_A0A0C4DGQ6
UniRef90:
UniRef90_Q96P16
UniRef50:
UniRef50_Q96P16
UniGene:
Hs.464912
CCDS:
CCDS77178.1,
CCDS11917.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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