| Type | Description |
|---|---|
| Definition | SMG8 nonsense mediated mRNA decay factor |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:30:00 | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. | 32469312 |
| 2021-01-16 16:00:00 | Recessive, Deleterious Variants in SMG8 Expand the Role of Nonsense-Mediated Decay in Developmental Disorders in Humans. | 33242396 |
| 2020-09-19 16:25:00 | Cryo-EM structure of SMG1-SMG8-SMG9 complex. | 31729466 |
| 2020-02-29 11:09:00 | This study reports the 3.45-A resolution cryo-EM structure of human SMG1-SMG8-SMG9, a phosphatidylinositol-3-kinase (PI(3)K)-related protein kinase (PIKK) complex central to messenger RNA surveillance. | 31792449 |
| 2013-12-14 11:26:00 | knockdown of SMG-8 produced the best effect for restoring defective mRNA and protein levels without affecting cell growth, cell-cycle progression, or endoplasmic reticulum stress in Ullrich congenital muscular dystrophy fibroblasts | 23983263 |
| Type | IDs |
|---|---|
| Synonymous | C17orf71 |
| Gene |
UniProtKB-ID:
SMG8_HUMAN
UniprotKB:
Q8ND04
UniParc:
UPI000006CCB5,
UPI00015C73DA,
UPI00015C73D9
EMBL:
BC020957,
AK026858,
AC099850,
CH471109,
AL834490,
AK001449,
BC031604,
AF349467
Ensembl:
ENSG00000167447
KO:
hsa:55181
|
| Nucleutide sequences |
EMBL-CDS:
AAH31604.1,
AAH20957.1,
BAB15576.1,
EAW94415.1,
CAD39148.1,
AAL83913.1,
BAA91699.1
Ensembl_TRS:
ENST00000543872,
ENST00000300917,
ENST00000578922
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000438748,
ENSP00000462119,
ENSP00000300917
RefSeq:
NP_060619.4
|
| Others |
UniRef100:
UniRef100_Q8ND04
UniRef90:
UniRef90_Q8ND04
UniRef50:
UniRef50_Q8ND04
UniGene:
Hs.7296
CCDS:
CCDS11615.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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