LINS1 - lines homolog 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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55180 LINS1

基因描述

Type	Description
Definition	lines homolog 1

研究结论

Date	Results	Publications
2020-01-18 12:15:00	A novel pathogenic variant of the LINS1 gene has been identified in a child with idiopathic mental retardation	31922598
2014-07-19 12:25:00	Study confirms that LINS, a modulator of the WNT pathway, is an indispensable gene to human cognition and this finding sheds further light on the importance of WNT signaling in human brain development and/or function.	23773660
2010-06-30 22:05:00	Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)	20379614
2010-01-21 00:00:00	Human WINS1 encoded 757 AA protein. Human WINS1 mRNA was expressed in adult testis, prostate, spleen, thymus, skeletal muscle, fetal kidney & brain. This is the first report on molecular cloning & initial characterization of human WINS1.	12119551

名称对应

Type	IDs
Synonymous	LINS, MRT27, WINS1
Gene	UniProtKB-ID: LINES_HUMAN UniprotKB: Q8NG48 UniParc: UPI00001AF0BD, UPI000013D795, UPI00001B09B7 EMBL: AC027020, AK292972, AB083157, AK001445, AC090695 Ensembl: ENSG00000140471 KO: hsa:55180
Nucleutide sequences	EMBL-CDS: BAF85661.1, BAB93864.1, BAA91696.1 Ensembl_TRS: ENST00000314742, ENST00000561308
Protein sequencees	Ensembl_PRO: ENSP00000318423, ENSP00000454200 RefSeq: NP_001339436.1, XP_005254998.1, XP_016877888.1, NP_001339437.1, XP_016877889.1, NP_001035706.2, XP_024305747.1, XP_024305748.1, XP_005255000.1
Others	UniRef100: UniRef100_Q8NG48 UniRef90: UniRef90_Q8NG48 UniRef50: UniRef50_Q8NG48 UniGene: Hs.105633 CCDS: CCDS10385.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Location

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Pubmed编号	文献信息	发表日期	相关基因
32694731	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nat Metab Michael Aregger , Keith A Lawson , Maximillian Billmann , Michael Costanzo , Amy H Y Tong , Katherine Chan , Mahfuzur Rahman , Kevin R Brown , Catherine Ross , Matej Usaj , Lucy Nedyalkova , Olga Sizova , Andrea Habsid , Judy Pawling , Zhen-Yuan Lin , Hala Abdouni , Cassandra J Wong , Alexander Weiss , Patricia Mero , James W Dennis , Anne-Claude Gingras , Chad L Myers , Brenda J Andrews , Charles Boone , Jason Moffat	2020-06-01	-
31922598	[Identification of LINS1 gene variant in a patient with severe mental retardation]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi Xinli Zhang , Liming Pan , Guosong Shen	2020-01-10	-
28986522	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Nat Commun Giulia Antoniali , Fabrizio Serra , Lisa Lirussi , Mikiei Tanaka , Chiara D'Ambrosio , Shiheng Zhang , Slobodanka Radovic , Emiliano Dalla , Yari Ciani , Andrea Scaloni , Mengxia Li , Silvano Piazza , Gianluca Tell	2017-10-06	-
28514442	Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper	2017-05-25	-
28181389	Novel LINS1 missense mutation in a family with non-syndromic intellectual disability. Am J Med Genet A Jayesh Sheth , Gyan Ranjan , Krati Shah , Riddhi Bhavsar , Frenny Sheth	2017-04-01	-
26167880	SR protein kinases promote splicing of nonconsensus introns. Nat. Struct. Mol. Biol. Jesse J Lipp , Michael C Marvin , Kevan M Shokat , Christine Guthrie	2015-08-01	-
23898208	Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein. Proc. Natl. Acad. Sci. U.S.A. Tory P Johnson , Karan Patel , Kory R Johnson , Dragan Maric , Peter A Calabresi , Rodrigo Hasbun , Avindra Nath	2013-08-13	tat, EBI3, TENM1, GPA33, IGSF6, BASP1, GPNMB, FGL2, PIM2, DNAJB4, GBP5, CISH, TAGAP, CR1, CRYZ, CSF2, CSF2RA, CYBB, FAAH2, DSC1, CERS3, MPEG1, FGF9, SBNO2, TRIM2, SLC7A11, FUCA1, NECTIN3, AK5, LAMP3, ANK3, CXCL1, HILPDA, GZMB, HLA-DQA1, FCRL6, IL1B, IL6, CXCL8, IL10, TNFRSF9, IL17A, IDO1, INHBA, INSL3, JAK3, KDR, KIT, SAMD12, LYZ, MFGE8, NFKBIA, NME2, SERPINB2, FOXP3, SFMBT1, PFN2, PIM1, LINS1, FBXO48, CDCA7L, PRKCA, SLC39A10, PSME2, PTGER2, NCEH1, RGL2, RAP1GDS1, RELB, RGS1, BCL3, BCL6, CEACAM1, CCL3, CCL4, CCL5, CCL19, CCL20, CCL22, CXCL5, CENPK, NFKBIZ, SLC14A1, FSCN1, STXBP1, VIPR1, YES1, EFL1, PPP1R3B, LONRF3, PARP9, SH3BGRL2, IFITM1, ADAM23, SOCS2, SOCS3, CLDN12, RNF185, EPSTI1
23773660	LINS, a modulator of the WNT signaling pathway, is involved in human cognition. Orphanet J Rare Dis Nadia A Akawi , Fatma Al-Jasmi , Aisha M Al-Shamsi , Bassam R Ali , Lihadh Al-Gazali	2013-06-17	-
21629298	Homozygosity mapping in 64 Syrian consanguineous families with non-specific intellectual disability reveals 11 novel loci and high heterogeneity. Eur J Hum Genet R Abou Jamra , Sigrun Wohlfart , Markus Zweier , Steffen Uebe , Lutz Priebe , Arif Ekici , Susanne Giesebrecht , Ahmad Abboud , Mohammed Ayman Al Khateeb , Mahmoud Fakher , Saber Hamdan , Amina Ismael , Safia Muhammad , Markus M NÃ¶then , Johannes Schumacher , AndrÃ© Reis	2011-11-01	-
20379614	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol. Med. Jed E Rose , FrÃ©dÃ©rique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl	2010-03-17	-

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