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55149 MTPAP

55149

MTPAP

mitochondrial poly(A) polymerase

protein-coding

Homo sapiens

基因描述

Type Description
Definition mitochondrial poly(A) polymerase

研究结论

Date Results Publications
2019-07-20 11:24:00 These results indicate that NDP52 and MTPAP form an autophagy receptor complex, which enhances autophagic elimination of damaged mitochondria. 30309841
2016-04-02 11:59:00 Mitochondrial poly(A) polymerase is able to add the discriminator adenosine to tRNATyr. 26354863
2015-10-31 11:37:00 The polymerase activity of mtPAP is modulated by LRPPRC/SLIRP; N478D mtPAP mutation decreases its activity and the alteration in poly(A) length causes dysregulation of post-transcriptional expression and lack of respiratory chain complexes. 25008111
2014-10-25 12:08:00 Mutation of the MTPAP gene results in a cellular phenotype of increased DNA damage, reduced repair kinetics, increased cell death by apoptosis, and reduced clonogenic survival after exposure to ionizing radiation. 24651433
2011-04-09 10:39:00 show that dimerization is required for the catalytic activity of PAPD1 21292163

名称对应

Type IDs
Synonymous PAPD1, SPAX4, TENT6
Gene
UniProtKB-ID: PAPD1_HUMAN
UniprotKB: Q9NVV4
UniParc: UPI000013EBEC, UPI0000070081
EMBL: AK001348, AK022188, AL122121, AL353796, AB194709, AY364242, CH471072, BC061703, AL161651
Ensembl: ENSG00000107951
KO: hsa:55149
Nucleutide sequences
EMBL-CDS: AAQ76801.1, CAH56395.1, BAD98252.1, BAB13981.1, BAA91641.1, EAW86014.1, AAH61703.1, EAW86015.1
Ensembl_TRS: ENST00000263063
Protein sequencees
Ensembl_PRO: ENSP00000263063
RefSeq: NP_060579.3
Others
UniRef100: UniRef100_Q9NVV4
UniRef90: UniRef90_Q9NVV4
UniRef50: UniRef50_Q9NVV4
UniGene: Hs.173946
CCDS: CCDS7165.1

全选

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