| Type | Description |
|---|---|
| Definition | protein phosphatase 1 regulatory subunit 7 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-14 11:57:00 | Structural and biochemical studies revealed that the concave side of SDS22 likely interacts with PP1 helices alpha5 and alpha6, which are distal from the binding sites of many previously described PP1 interactors. Accordingly, SDS22 would act as a "third" subunit of multiple PP1 holoenzymes. The crystal structure of SDS22 also revealed a large basic surface patch that enables binding of a phosphorylated form of BCLAF1. | 30661852 |
| 2019-10-05 10:04:00 | Ppp1r7 may play a central role in regulating the PP1 interactome by acting as a competitive molecular "sponge" of PP1c. | 29669786 |
| 2019-02-16 10:34:00 | our findings revealed that protein phosphatase regulatory subunit SDS22 functions as a putative tumor suppressor by dephosphorylation-mediated inactivation of AKT and MAPK signaling pathways. | 30500680 |
| 2017-10-14 11:23:00 | a Fra-1-miR-134 axis drives a positive feedback loop that amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. | 27685628 |
| 2017-05-20 13:46:00 | Mechanistically, the phosphorylation of Sds22 by PLK1 strengthens the binding of Sds22 to PP1 and inhibits the dephosphorylation of Thr(232) of Aurora B to ensure a robust, error-free metaphase-anaphase transition. | 27557660 |
| Type | IDs |
|---|---|
| Synonymous | SDS22 |
| Gene |
UniProtKB-ID:
PP1R7_HUMAN,
A0A140VK83_HUMAN
UniprotKB:
Q15435,
A0A140VK83
UniParc:
UPI000173A635,
UPI000006DDB1,
UPI000006E65A,
UPI000006FE9F,
UPI000006FD15
EMBL:
AF067131,
AF067134,
BT007296,
AK294043,
AF067132,
BT020134,
BC000910,
Z50749,
BC013001,
CH471063,
AF067130,
HM005623,
BC012397,
AF067133,
AF067135,
AF067136,
AC005237
Ensembl:
ENSG00000115685
KO:
hsa:5510
|
| Nucleutide sequences |
EMBL-CDS:
AAV38936.1,
AAH12397.1,
AAH13001.1,
AAP35960.1,
CAA90626.1,
EAW71243.1,
AAD26612.1,
AAD26613.1,
AAD26611.1,
BAG57395.1,
AAD26610.1,
AAH00910.1,
EAW71244.1,
AEE61220.1
Gene_ORFName:
hCG_33049
Ensembl_TRS:
ENST00000401987,
ENST00000406106,
ENST00000272983,
ENST00000407025,
ENST00000234038,
ENST00000402734
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000385657,
ENSP00000385466,
ENSP00000234038,
ENSP00000385022,
ENSP00000272983,
ENSP00000385012
RefSeq:
NP_001269342.1,
NP_001269340.1,
NP_001269339.1,
NP_001269341.1,
XP_011509690.1,
NP_001269338.1,
NP_002703.1,
NP_001269343.1
|
| Others |
UniRef100:
UniRef100_Q15435
UniRef90:
UniRef90_Q15435
UniRef50:
UniRef50_Q15435
UniGene:
Hs.36587
CCDS:
CCDS63194.1,
CCDS63193.1,
CCDS63190.1,
CCDS63192.1,
CCDS2546.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员