| Type | Description |
|---|---|
| Definition | protein phosphatase 1 regulatory subunit 3A |
| Date | Results | Publications |
|---|---|---|
| 2019-07-06 13:00:00 | Genome-wide genotyping study and gene expression measurements of healthy and failing human hearts revealed important regulators and cardiac expression quantitative trait loci. PPP1R3A emerges as a regulator whose network connectivity changes significantly between health and disease. RNA sequencing after PPP1R3A knockdown validates network-based predictions and establish PPP1R3A as a central regulator in heart failure. | 31235787 |
| 2018-10-27 11:27:00 | Variant in PPP1R3A is associated with type 2 diabetes. | 29948331 |
| 2018-02-24 11:46:00 | In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. | 27587435 |
| 2013-09-07 10:44:00 | results demonstrate that hScrib acts as a scaffold to integrate the control of the PP1gamma and ERK signaling pathways and explains how disruption of hScrib localisation can contribute towards the development of human malignancy | 23359326 |
| 2010-01-21 00:00:00 | We describe a family in which five individuals with severe insulin resistance, but no unaffected family members, were compound heterozygous with respect to frameshift/premature stop mutations in two unlinked genes, PPARG and PPP1R3A | 12118251 |
| Type | IDs |
|---|---|
| Synonymous | GM, PP1G, PPP1R3 |
| Gene |
UniProtKB-ID:
PPR3A_HUMAN
UniprotKB:
Q16821
UniParc:
UPI000006D1C2,
UPI000013DDAA
EMBL:
BC126451,
AF024577,
AF024576,
CH236947,
AC092465,
BC126453,
AF024579,
AC093598,
X78578,
AF024578
Ensembl:
ENSG00000154415
KO:
hsa:5506
|
| Nucleutide sequences |
EMBL-CDS:
AAP22361.1,
AAB94596.1,
AAS07492.1,
CAA55316.1,
AAI26452.1,
AAB94597.1,
AAI26454.1,
EAL24370.1
Ensembl_TRS:
ENST00000284602,
ENST00000284601
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000284601,
ENSP00000284602
RefSeq:
NP_002702.2,
XP_005250530.1
|
| Others |
UniRef100:
UniRef100_Q16821
UniRef90:
UniRef90_Q16821
UniRef50:
UniRef50_Q16821
UniGene:
Hs.458309
CCDS:
CCDS5759.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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