| Type | Description |
|---|---|
| Definition | pleckstrin homology domain interacting protein |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:16:00 | PHIP drives glioblastoma motility, invasion, and angiogenesis. PHIP regulates expression of focal adhesion proteins and physically interacts with vinculin, mechanisms by which it promotes tumor cell motility and invasion. The presence of elevated PHIP copy number in distinct molecular glioblastoma subtypes provides additional support for its importance to glioblastoma biology. | 32273388 |
| 2020-04-25 11:34:00 | During mitosis, CRL4 dissociates from RepID and replaces it with RB Binding Protein 7 (RBBP7), which ubiquitinates the SAC mediator BUB3 to enable mitotic exit. | 31911655 |
| 2019-11-09 11:50:00 | as elevated PHIP copy number appears to be selected for during the progression of primary to metastatic melanoma, these results confirm PHIP as a promising therapeutic target for melanoma. | 29776954 |
| 2018-12-22 10:15:00 | The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. | 30018425 |
| 2014-04-12 10:51:00 | These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. | 24005052 |
| Type | IDs |
|---|---|
| Synonymous | BRWD2, DCAF14, DIDOD, WDR11, ndrp |
| Gene |
UniProtKB-ID:
PHIP_HUMAN
UniprotKB:
Q8WWQ0
UniParc:
UPI000013DA40
EMBL:
AL356776,
BC008909,
AK075124,
BC021905,
CH471051,
AL450327,
DQ924532,
AK057039,
BC137488,
AJ303102,
AF310250,
BC081569,
AL161957
Ensembl:
ENSG00000146247
KO:
hsa:55023
|
| Nucleutide sequences |
EMBL-CDS:
BAB71353.1,
CAC83118.1,
AAH21905.1,
AAG45145.1,
EAW48718.1,
AAH08909.2,
AAI37489.1,
ABK76299.1,
CAH10776.1,
BAC11417.1,
AAH81569.1
Ensembl_TRS:
ENST00000275034
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000275034
RefSeq:
XP_016866478.1,
XP_011534220.1,
XP_016866479.1,
XP_005248786.1,
XP_011534221.1,
NP_060404.4
|
| Others |
UniRef100:
UniRef100_Q8WWQ0
UniRef90:
UniRef90_Q8WWQ0
UniRef50:
UniRef50_Q8WWQ0
UniGene:
Hs.511817,
Hs.606356
CCDS:
CCDS4987.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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