| Type | Description |
|---|---|
| Definition | histone PARylation factor 1 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:52:00 | HPF1 remodels the active site of to enable the serine ADP-ribosylation of histones. | 33589610 |
| 2020-12-26 13:15:00 | Bridging of nucleosome-proximal DNA double-strand breaks by enhances its interaction with HPF1. | 33141820 |
| 2020-10-24 14:12:00 | Bridging of DNA breaks activates to modify chromatin. | 32939087 |
| 2020-06-06 11:37:00 | HPF1 completes the active site for DNA damage-induced ADP-ribosylation; as HPF1 forms a joint active site with or our data implicate HPF1 as an important determinant of the response to clinical Pduanyu37 inhibitors | 32028527 |
| 2019-07-20 12:40:00 | Here, the authors show that serine ADP-ribosylation represents the major fraction of ADP-ribosylation synthesized after DNA damage in mammalian cells and that globally serine ADP-ribosylation is dependent on HPF1, and ARH3. In the absence of HPF1, glutamate/aspartate becomes the main target residues for ADP-ribosylation. | 29480802 |
| Type | IDs |
|---|---|
| Synonymous | C4orf27 |
| Gene |
UniProtKB-ID:
HPF1_HUMAN
UniprotKB:
Q9NWY4
UniParc:
UPI000013D19D
EMBL:
AC106878,
AL136673,
BC010367,
AK000541
Ensembl:
ENSG00000056050
KO:
hsa:54969
|
| Nucleutide sequences |
EMBL-CDS:
CAB66608.1,
AAH10367.1,
BAA91241.1
Ensembl_TRS:
ENST00000393381
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000406598
RefSeq:
NP_060337.2
|
| Others |
UniRef100:
UniRef100_Q9NWY4
UniRef90:
UniRef90_Q9NWY4
UniRef50:
UniRef50_Q9NWY4
UniGene:
Hs.406756
CCDS:
CCDS3813.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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