| Type | Description |
|---|---|
| Definition | ADP-ribosylhydrolase like 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:58:00 | AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair. | 32753484 |
| 2020-09-12 16:06:00 | Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair. | 32636369 |
| 2020-05-16 10:56:00 | Study identified a family with an ARH3 gene mutation that resulted in a truncated, inactive protein. The 8-year-old proband exhibited a progressive neurodegeneration phenotype. Parthanatos was observed in neurons of the patient's deceased sibling, and an older sibling exhibited a mild behavioral phenotype. Patient's fibroblasts were more sensitive to H2O2 stress-induced poly(ADP-ribose) accumulation and cell death. | 30830864 |
| 2019-07-20 12:40:00 | Here, the authors show that serine ADP-ribosylation represents the major fraction of ADP-ribosylation synthesized after DNA damage in mammalian cells and that globally serine ADP-ribosylation is dependent on HPF1, and ARH3. In the absence of HPF1, glutamate/aspartate becomes the main target residues for ADP-ribosylation. | 29480802 |
| 2019-05-18 10:41:00 | ADPRHL2 was virtually absent in available affected individuals' fibroblasts. | 30401461 |
| Type | IDs |
|---|---|
| Synonymous | ARH3, CONDSIAS |
| Gene |
UniProtKB-ID:
ADPRS_HUMAN,
B7ZAN4_HUMAN
UniprotKB:
Q9NX46,
B7ZAN4
UniParc:
UPI0000D4D5BA,
UPI0000039EBB
EMBL:
CR457237,
AJ427295,
AK316349,
BC014169,
AL138787,
AJ313333,
CH471059,
AF212236,
AK000453,
AK223037
Ensembl:
ENSG00000116863
KO:
hsa:54936
|
| Nucleutide sequences |
EMBL-CDS:
CAG33518.1,
CAD20316.1,
AAK14922.1,
CAC85940.1,
BAA91174.1,
BAD96757.1,
AAH14169.1,
BAH14720.1,
EAX07389.1
Gene_ORFName:
hCG_38289
Ensembl_TRS:
ENST00000373178
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000362273
RefSeq:
XP_011539938.1,
NP_060295.1
|
| Others |
UniRef100:
UniRef100_Q9NX46
UniRef90:
UniRef90_Q9NX46
UniRef50:
UniRef50_Q9NX46
UniGene:
Hs.18021
CCDS:
CCDS402.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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