| Type | Description |
|---|---|
| Definition | nuclear receptor binding SET domain protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:35:00 | Elevated NSD3 histone methylation activity drives squamous cell lung cancer. | 33536620 |
| 2021-03-20 13:34:00 | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases. | 33361816 |
| 2020-07-18 10:42:00 | The observation that certain metabolic pathways are differentially regulated by NSD3s and Pdp3 suggests that, despite the structural similarity between their PWWP domains, the two proteins act by unique mechanisms and may recruit different downstream signaling complexes. | 30320908 |
| 2018-06-09 11:17:00 | Studies showed that depletion of NSD3 in osteosarcoma cell lines inhibited cell proliferation and survival, and induced cell apoptosis. RNA sequence analysis of tumor cell lines with NSD3 deletion revealed that NSD3 functions as either a transcriptional activator or a repressor. These results suggest that NSD3 may function as an oncogenic driver in osteosarcoma. | 28901481 |
| 2018-03-24 10:28:00 | Results extend the in vitro results and show that targeted expression of NSD3 to the mammary gland of FVB mice is oncogenic, consistent with the hypothesis that NSD3 is an important driver oncogene in human breast cancer. | 28484924 |
| Type | IDs |
|---|---|
| Synonymous | KMT3F, KMT3G, WHISTLE, WHSC1L1, pp14328 |
| Gene |
UniProtKB-ID:
NSD3_HUMAN
UniprotKB:
Q9BZ95
UniParc:
UPI0001917051,
UPI0000071E85,
UPI0000E56EFD,
UPI0000E56EFE,
UPI000006F297
EMBL:
AC087623,
BC012059,
BC115006,
AJ295992,
AK000360,
BC143510,
BC113469,
AC087362,
CH471080,
AK022560,
AK127594,
AF332468,
AF255649,
BC101717,
AF332469,
AJ295991,
BC062631,
AJ295990,
BC107734
Ensembl:
ENSG00000147548
KO:
hsa:54904
|
| Nucleutide sequences |
EMBL-CDS:
AAI13470.1,
AAK00354.1,
EAW63320.1,
AAI15007.1,
AAG44637.1,
CAC28350.1,
AAK00355.1,
AAI07735.1,
CAC28352.1,
BAA91110.1,
AAI43511.1,
BAB14099.1,
EAW63321.1,
AAH62631.1,
CAC28351.1,
AAI01718.1,
AAH12059.1
Gene_ORFName:
DC28
Ensembl_TRS:
ENST00000433384,
ENST00000527502,
ENST00000316985,
ENST00000317025
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000434730,
ENSP00000313410,
ENSP00000313983,
ENSP00000393284
RefSeq:
NP_060248.2,
NP_075447.1
|
| Others |
UniRef100:
UniRef100_Q9BZ95
UniRef90:
UniRef90_Q9BZ95
UniRef50:
UniRef50_Q9BZ95
UniGene:
Hs.608111
CCDS:
CCDS6105.1,
CCDS43729.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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