| Type | Description |
|---|---|
| Definition | SNF related kinase |
| Date | Results | Publications |
|---|---|---|
| 2018-11-24 12:13:00 | Study shows that TRIB3 binds to SNRK, and downregulates UCP3 through PPARalpha. SNRK is increased in cardiomyopathy patients, and SNRK reduces infarct size after ischaemia/reperfusion. SNRK also decreases cardiac cell death in a UCP3-dependent manner. | 28117339 |
| 2018-01-20 11:26:00 | Report the crystal structure of an N-terminal SNRK fragment containing kinase and adjacent ubiquitin-associated (UBA) domains. This structure shows that the UBA domain binds between the N- and C-lobes of the kinase domain. The mode of UBA binding in SNRK largely resembles that in AMPK and brain specific kinase (BRSK), however, unique interactions play vital roles in stabilizing the KD-UBA interface of SNRK. | 29061304 |
| 2017-11-04 12:46:00 | SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart. | 27780848 |
| 2017-10-07 12:09:00 | Differential expression of SNRK in early versus late stage disease suggests specific roles for SNRK in ovarian cancer metastasis. | 28722495 |
| 2015-10-26 15:31:00 | SNRK inhibits colon cancer cell proliferation through calcyclin-binding protein up-regulation and beta-catenin degradation, which results in reduced proliferation signaling. | 22874833 |
| Type | IDs |
|---|---|
| Synonymous | HSNFRK |
| Gene |
UniProtKB-ID:
SNRK_HUMAN,
E7EUC4_HUMAN,
A0A024R2Y6_HUMAN,
A8K5P5_HUMAN,
B4DHM9_HUMAN
UniprotKB:
Q9NRH2,
E7EUC4,
A0A024R2Y6,
A8K5P5,
B4DHM9
UniParc:
UPI00017A72D1,
UPI00000558E4,
UPI00006A7817,
UPI000198C94E,
UPI00015DA8BC
EMBL:
AK295187,
BC071567,
AF226044,
CH471055,
AC097638,
CR749621,
AK291360,
AK000231,
AK314376,
D43636,
AC104434,
AC104184
Ensembl:
ENSG00000163788
KO:
hsa:54861
|
| Nucleutide sequences |
EMBL-CDS:
AAH71567.1,
EAW64693.1,
BAA07744.2,
AAF86944.1,
BAG37003.1,
CAH18415.1,
BAA91023.1,
EAW64694.1,
BAF84049.1,
BAG58191.1
Gene_ORFName:
hCG_26802
Ensembl_TRS:
ENST00000296088,
ENST00000454177,
ENST00000429705,
ENST00000437827
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000296088,
ENSP00000411375,
ENSP00000401246,
ENSP00000409516
RefSeq:
NP_060189.3,
NP_001317679.1,
NP_001094064.1,
XP_005265302.1
|
| Others |
UniRef100:
UniRef100_B4DHM9,
UniRef100_Q9NRH2,
UniRef100_A8K5P5
UniRef90:
UniRef90_G3RE14,
UniRef90_Q9NRH2,
UniRef90_G1LH92
UniRef50:
UniRef50_Q9NRH2,
UniRef50_Q8VDU5
UniGene:
Hs.476052
CCDS:
CCDS43075.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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