TRIT1 - tRNA isopentenyltransferase 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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54802 TRIT1

基因描述

Type	Description
Definition	tRNA isopentenyltransferase 1

研究结论

Date	Results	Publications
2020-07-25 12:12:00	Targeting mitochondrial and cytosolic substrates of TRIT1 isopentenyltransferase: Specificity determinants and tRNA-i6A37 profiles	32324744
2017-07-01 12:19:00	We show that dysfunctional TRIT1 results in decreased levels of select mitochondrial proteins. Our findings confirm the TRIT1 disease association and advance the phenotypic and molecular understanding of this disorder.	28185376
2017-05-06 10:38:00	characterize TRIT1 as a novel human amyloid fiber forming protein. We discuss these data in light of TRIT1's functional roles and possible implications for disease	27984194
2015-06-27 13:23:00	patient cells bearing the p.Arg323Gln TRIT1 mutation are severely deficient in i6A37 in both cytosolic and mitochondrial tRNAs	24901367
2015-03-07 11:05:00	In light of this additional nuclear role for Mod5 we discuss the proposed role of the human homologue of Mod5, TRIT1, as a tumor suppressor protein.[review]	25261850

名称对应

Type	IDs
Synonymous	COXPD35, GRO1, IPPT, IPT, IPTase, MOD5, hGRO1
Gene	UniProtKB-ID: MOD5_HUMAN, Q3T7C7_HUMAN, Q53F11_HUMAN UniprotKB: Q9H3H1, Q3T7C7, Q53F11 UniParc: UPI00005ADF6A, UPI000049E31A, UPI00003B2591, UPI000004A018, UPI00000716D2, UPI000006D117, UPI000050A9D8, UPI000006E2FB EMBL: AY052768, BC128155, CR457226, AY702945, AK000068, AY303390, BC107569, AY702944, AK223478, AY702933, AF074918, AL033527, BC010741 Ensembl: ENSG00000043514 KO: hsa:54802
Nucleutide sequences	EMBL-CDS: AAP60111.1, AAI28156.1, BAA90923.1, AAL14107.1, AAW63405.1, AAG31324.1, AAH10741.2, AAW63406.1, AAI07570.1, CAG33507.1, AAW63394.1, BAD97198.1 Ensembl_TRS: ENST00000441669, ENST00000316891, ENST00000537440, ENST00000372818
Protein sequencees	Ensembl_PRO: ENSP00000388333, ENSP00000437700, ENSP00000321810, ENSP00000361905 RefSeq: XP_006710769.1, XP_005271011.1, NP_060116.2, NP_001299620.1, NP_001299621.1
Others	UniRef100: UniRef100_Q9H3H1, UniRef100_Q53F11 UniRef90: UniRef90_Q9H3H1 UniRef50: UniRef50_Q9H3H1 UniGene: Hs.356554 CCDS: CCDS81302.1, CCDS81303.1, CCDS30681.1

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32324744	Targeting mitochondrial and cytosolic substrates of TRIT1 isopentenyltransferase: Specificity determinants and tRNA-i6A37 profiles. PLoS Genet Abdul Khalique , Sandy Mattijssen , Alexander F Haddad , Shereen Chaudhry , Richard J Maraia	2020-04-01	-
30021884	Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck	2018-10-01	-
27984194	The human tRNA-modifying protein, TRIT1, forms amyloid fibers in vitro. Gene T J Waller , D F Read , D R Engelke , P J Smaldino	2017-05-15	-
28185376	Matchmaking facilitates the diagnosis of an autosomal-recessive mitochondrial disease caused by biallelic mutation of the tRNA isopentenyltransferase (TRIT1) gene. Hum. Mutat. Kristin D Kernohan , David A Dyment , Mihaela Pupavac , Zvi Cramer , Arran McBride , Genevieve Bernard , Isabella Straub , Martine Tetreault , Taila Hartley , Lijia Huang , Erick Sell , Jacek Majewski , David S Rosenblatt , Eric Shoubridge , Aziz Mhanni , Tara Myers , Virginia Proud , Samanta Vergano , Brooke Spangler , Emily Farrow , Jennifer Kussman , Nicole Safina , Care4Rare Consortium , Carol Saunders , Kym M Boycott , Isabelle Thiffault	2017-05-01	-
25814554	Phospho-tyrosine dependent protein-protein interaction network. Mol. Syst. Biol. Arndt Grossmann , Nouhad Benlasfer , Petra Birth , Anna Hegele , Franziska Wachsmuth , Luise Apelt , Ulrich Stelzl	2015-03-01	SH2B3, SH2D3A, HUWE1, FSBP, TSPAN2, TNK2, SPRY2, APBB3, TRDN, ANAPC10, BAIAP2, ZNHIT1, SEMA4D, UBD, CENPB, POLR3F, RAI2, SDCCAG8, FRS3, FRS2, PGRMC1, CYP46A1, ARID5A, NMU, RALBP1, YWHAQ, LECT1, CYB561D2, RCAN3, CAPN10, FSTL1, RASSF1, CHN2, TP53RK, EFHC1, OSBPL6, C1QTNF3, DDIT4L, FAM46B, CKM, TM4SF19, RBP7, OLIG1, CLNK, SH2D1B, TWIST2, ASCL4, SOCS4, COX6B2, GABPB2, SHE, VSTM2L, C22orf39, PPP1R21, SCLT1, PACRGL, SETD9, C6orf141, MAGEC3, DCAF12L1, CRK, CRKL, CRP, TCP10L, ASB8, ASB9, CRYBA2, CSK, DUSP18, FAM117B, PLB1, IQUB, WBSCR27, CYP2C8, DBN1, PAQR7, DDX5, LIX1, GLIS3, DOK1, EPYC, DTNA, E2F2, E2F6, PHC2, KRTCAP2, ELK1, ADCK5, EPS8, AKT1, ESD, MECOM, EYA3, EZH2, FABP7, FANCG, MPEG1, LNX2, FAM217A
25261850	The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer. Gene P J Smaldino , D F Read , M Pratt-Hyatt , A K Hopper , D R Engelke	2015-02-01	TRIT1
24901367	Defective i6A37 modification of mitochondrial and cytosolic tRNAs results from pathogenic mutations in TRIT1 and its substrate tRNA. PLoS Genet John W Yarham , Tek N Lamichhane , Angela Pyle , Sandy Mattijssen , Enrico Baruffini , Francesco Bruni , Claudia Donnini , Alex Vassilev , Langping He , Emma L Blakely , Helen Griffin , Mauro Santibanez-Koref , Laurence A Bindoff , Ileana Ferrero , Patrick F Chinnery , Robert McFarland , Richard J Maraia , Robert W Taylor	2014-06-01	-
24126054	Human cells have a limited set of tRNA anticodon loop substrates of the tRNA isopentenyltransferase TRIT1 tumor suppressor. Mol. Cell. Biol. Tek N Lamichhane , Sandy Mattijssen , Richard J Maraia	2013-12-01	TRIT1
23349019	Association of polymorphisms and haplotype in the region of TRIT1, MYCL1 and MFSD2A with the risk and clinicopathological features of gastric cancer in a southeast Chinese population. Carcinogenesis Shuqin Chen , Zhihua Zheng , Jianqing Tang , Xiandong Lin , Xiaojun Wang , Jianyin Lin	2013-05-01	MYCL, TRIT1, MFSD2A
23455924	A Y2H-seq approach defines the human protein methyltransferase interactome. Nat. Methods Mareike Weimann , Arndt Grossmann , Jonathan Woodsmith , Ziya Ãzkan , Petra Birth , David Meierhofer , Nouhad Benlasfer , Taras Valovka , Bernd Timmermann , Erich E Wanker , Sascha Sauer , Ulrich Stelzl	2013-04-01	HMGXB4, NR1H3, AKAP9, PRMT3, SPRY2, PRMT5, MCRS1, ECI2, BAIAP2, TADA3, SYNCRIP, CARM1, BATF, SLU7, POLR3F, MYL12A, STARD10, UTP14A, MALT1, SPIN1, SF3B2, NUDT21, ATE1, RASSF1, RASSF8, PMF1, SNF8, PNKP, CDCA5, OIP5, LENG8, HAUS1, NOSTRIN, CCDC151, DNTTIP1, RAB3IP, SSX2IP, CLK1, CLK3, ZNF641, IKBIP, AEBP2, FRMD6, CDYL2, KRT222, ZNF57, GABPB2, UBXN10, TSACC, ZNF280A, NUDCD2, ASB10, VPS37A, FOXR2, ZFP28, FAM76B, ZNF480, CCDC155, C20orf196, LCA5L, SMYD1, SPICE1, FGD5, SAMD3, WBSCR27, C8orf48, AK8, ADSS, DYX1C1, DAXX, SPRED1, C18orf54, FAM9A, DXO, PHC2, SPATA24, C8orf74, ETV3, MECOM, EWSR1, EZH2, JMJD1C, ZUFSP, MTF2, CEP162, BAHD1, WDFY3, KDM1A, KDM4B, SEPT6, DIP2A, MLC1, JMJD6, ITGB3BP, BRD4, TTC33, ZKSCAN5, STAC3, FUS

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