| Type | Description |
|---|---|
| Definition | OTU deubiquitinase 4 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:44:00 | OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex. | 32973272 |
| 2020-07-25 10:08:00 | Knockdown of OTUD4 in HeLa cells resulted in defects in stress granule formation and led to apoptotic cell death | 31138677 |
| 2019-01-12 12:10:00 | Authors demonstrate that the deubiquitinase OTUD4, which nominally encodes a K48-specific deubiquitinase, is phosphorylated near its catalytic domain, activating a latent K63-specific deubiquitinase. Besides phosphorylation, this latter activity requires an adjacent ubiquitin-interacting motif, which increases the affinity of OTUD4 for K63-linked chains. | 29395066 |
| 2016-06-28 10:27:00 | There is an evolutionary loss of activity in de-ubiquitylating enzymes of the OTU family, OTUD4, otu, and CG3251. | 26588485 |
| 2015-08-29 10:42:00 | OTUD4 is a positive regulator of ALKBH2 and ALKBH3, two DNA demethylases critical for alkylation repair. | 25944111 |
| Type | IDs |
|---|---|
| Synonymous | DUBA6, HIN1, HSHIN1 |
| Gene |
UniProtKB-ID:
OTUD4_HUMAN
UniprotKB:
Q01804
UniParc:
UPI000020B524,
UPI0000DA6D4D,
UPI0000E825C1,
UPI000012C721
EMBL:
AC096757,
AK302581,
AK056597,
BC118572,
BC118653,
AB028969,
CH471056,
AL137460,
DQ427109,
X68242,
BC057242
Ensembl:
ENSG00000164164
KO:
hsa:54726
|
| Nucleutide sequences |
EMBL-CDS:
BAA82998.2,
AAH57242.2,
EAX05045.1,
CAA48313.1,
CAB70748.1,
ABD72605.1,
EAX05046.1,
BAB71229.1,
BAG63836.1,
AAI18573.1,
AAI18654.1
Ensembl_TRS:
ENST00000454497,
ENST00000447906,
ENST00000509620
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000409279,
ENSP00000424192,
ENSP00000395487
RefSeq:
NP_001352986.1,
NP_001096123.1,
XP_011530344.1,
NP_001352987.1,
XP_011530342.2,
XP_011530343.2,
NP_059963.1
|
| Others |
UniRef100:
UniRef100_Q01804
UniRef90:
UniRef90_Q01804
UniRef50:
UniRef50_Q01804
UniGene:
Hs.270851
CCDS:
CCDS3764.1,
CCDS47139.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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