| Type | Description |
|---|---|
| Definition | gasdermin E |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 10:48:00 | tumor GSDME acts as a tumor suppressor by activating pyroptosis, enhancing anti-tumor immunity | 32188940 |
| 2019-05-11 12:20:00 | Using an in vivo mouse model of B16 melanoma, study demonstrated that GSDME may possess a bona fide tumor suppressor activity as GSDME-deficient melanoma cells form and grow larger tumors than their wild-type counterparts. | 30976076 |
| 2019-01-26 11:47:00 | Authors show that caspase-8 activation during TAK1 inhibition results in cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME) in murine macrophages, resulting in pyroptosis. | 30381458 |
| 2019-01-26 10:58:00 | gasdermin-D is required for IL-1beta secretion by macrophages, dendritic cells and partially in neutrophils, and that secretion is a cell-lysis-independent event. | 29274245 |
| 2018-11-17 11:25:00 | Because DFNA5-induced secondary necrosis and GSDMD-induced pyroptosis are dependent on CASP3 activation, we propose that they are forms of programmed necrosis. | 28045099 |
| Type | IDs |
|---|---|
| Synonymous | 2310037D07Rik, 4932441K13Rik, Dfna5, Dfna5h, EG14210, Fin15 |
| Gene |
UniProtKB-ID:
GSDME_MOUSE
UniprotKB:
Q9Z2D3
UniParc:
UPI0000003F23
EMBL:
AK016561,
AF073309
Ensembl:
ENSMUSG00000029821
KO:
mmu:54722
|
| Nucleutide sequences |
EMBL-CDS:
BAB30305.1,
AAC69325.1
Ensembl_TRS:
ENSMUST00000031845,
ENSMUST00000170142
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000031845,
ENSMUSP00000126759
RefSeq:
XP_036008131.1,
NP_061239.1,
XP_006506465.1,
XP_030111367.1
|
| Others |
UniRef100:
UniRef100_Q9Z2D3
UniRef90:
UniRef90_Q9Z2D3
UniRef50:
UniRef50_O60443
UniGene:
Mm.248361
CCDS:
CCDS20130.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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