| Type | Description |
|---|---|
| Definition | tyrosine kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-02 12:50:00 | TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis. | 32149730 |
| 2020-03-28 12:14:00 | The study shows that poultry dust controls the induction of immune and inflammatory mediator expression via a cellular pathway involving oxidative stress-mediated activation by TYK2 and EGFR tyrosine kinases. | 31042082 |
| 2020-01-11 10:54:00 | our findings provide the first evidence, to our knowledge, for a key role of TYK2 in the host environment in promoting NK cell maturation and antitumor activity. | 30718299 |
| 2019-12-14 10:38:00 | TYK2(P) diminishes IL-12, IL-23, and IFN I signaling and that its protective effect is most likely manifest in the setting of autoimmune triggers that concurrently dysregulate at least two of these important signaling cascades. | 30740104 |
| 2017-12-30 11:53:00 | TYK2 genetic variants are differentially associated with common autoimmune diseases | 27807284 |
| Type | IDs |
|---|---|
| Synonymous | JTK1 |
| Gene |
UniProtKB-ID:
TYK2_MOUSE,
E9QJS1_MOUSE
UniprotKB:
Q9R117,
E9QJS1
UniParc:
UPI00005AD2B6,
UPI0000D8B259
EMBL:
AK159303,
BC019789,
AF173032,
AF052607,
BC094240,
AC163637,
CH466522
Ensembl:
ENSMUSG00000032175
KO:
mmu:54721
|
| Nucleutide sequences |
EMBL-CDS:
EDL25160.1,
AAD49423.1,
BAE34973.1,
AAC34580.2,
AAH94240.1,
AAH19789.1
Ensembl_TRS:
ENSMUST00000214454,
ENSMUST00000216874,
ENSMUST00000001036
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000150214,
ENSMUSP00000150354,
ENSMUSP00000001036
RefSeq:
XP_006510557.1,
NP_061263.2,
NP_001192241.1,
XP_011240881.1,
XP_006510555.1,
XP_030100315.1,
XP_030100316.1
|
| Others |
UniRef100:
UniRef100_E9QJS1,
UniRef100_Q9R117
UniRef90:
UniRef90_Q9R117
UniRef50:
UniRef50_Q9R117
UniGene:
Mm.20249,
Mm.450004
CCDS:
CCDS90510.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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