| Type | Description |
|---|---|
| Definition | membrane associated ring-CH-type finger 5 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-27 14:42:00 | MARCH5 mediates NOXA-dependent MCL1 degradation driven by kinase inhibitors and integrated stress response activation. | 32484436 |
| 2020-09-05 13:58:00 | Mitochondria ubiquitin ligase, MARCH5 resolves hepatitis B virus X protein aggregates in the liver pathogenesis. | 31819032 |
| 2020-05-23 10:07:00 | Ubiquitylation of MITOL at K268 by Parkin is required for p97/VCP-dependent redistribution from mitochondria to peroxisomes. | 31602805 |
| 2019-12-28 11:12:00 | Study identified IRE1a as a novel substrate for MITOL. MITOL modifies the lysine (K) 481 of IRE1a by adding a K63-linked polyubiquitin chain, which in turn suppresses the activity and oligomerization of IRE1a. These data provide evidence that MITOL can directly regulate IRE1a through the mitochondria-associated ER membrane (MAM) and thus play an important role in determining cell fate under ER stress. | 31368599 |
| 2019-11-23 11:18:00 | Data demonstrate a lower abundance of MARCH5 protein in white adipose tissue from the obese group with subsequently impaired fasting blood glucose levels than in lean individuals with normal glucose tolerance, confirming that MARCH5 is reduced in the setting of obesity and metabolic dysregulation. | 30512991 |
| Type | IDs |
|---|---|
| Synonymous | MARCH-V, MITOL, RNF153 |
| Gene |
UniProtKB-ID:
MARH5_HUMAN
UniprotKB:
Q9NX47
UniParc:
UPI000006D0BC
EMBL:
AL161652,
AB191202,
AL158040,
BC015480,
AK000452
Ensembl:
ENSG00000198060
KO:
hsa:54708
|
| Nucleutide sequences |
EMBL-CDS:
BAF02285.1,
BAA91173.1,
AAH15480.1
Ensembl_TRS:
ENST00000358935
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000351813
RefSeq:
NP_060294.1,
XP_011538188.1
|
| Others |
UniRef100:
UniRef100_Q9NX47
UniRef90:
UniRef90_Q9NX47
UniRef50:
UniRef50_Q9NX47
UniGene:
Hs.573490
CCDS:
CCDS7420.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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