| Type | Description |
|---|---|
| Definition | platelet-derived growth factor, C polypeptide |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 12:28:00 | In addition to its key role in mediating renal fibrosis, study identified PDGF-C as a mediator of hypertension via effects on renal vasculature and on the renin-angiotensin system in "Alport" mice, a model of progressive renal fibrosis. | 30827511 |
| 2019-05-25 10:53:00 | paracrine crosstalk between cancer cells expressing platelet-derived growth factor (PDGF)-CC and cancer-associated fibroblasts expressing the cognate receptors in human basal-like mammary carcinomas, was identified. | 29529015 |
| 2018-06-30 10:19:00 | Results provide both in vitro and in vivo evidence that Mac-1 acting together with LRP1 facilitates PDGF-CC activation by thrombolytic tissue plasminogen activator in the neurovascular unit. The requirement of both Mac-1 and LRP1 for efficient activation of PDGF-CC by tPA provides a novel mechanism that helps limit PDGFRalpha signaling in the neurovascular unit. | 28725968 |
| 2016-10-01 10:46:00 | High glucose-mediated induction of PDGF-C via ChREBP in mesangial cells contributes to the development of glomerular mesangial expansion in diabetes. | 27033449 |
| 2016-05-28 12:25:00 | PDGF-CC neutralization or deficiency was not associated with preservation or accelerated loss of peritubular capillaries, suggesting no significant pro-angiogenic effects of PDGF-CC during renal fibrosis | 26216283 |
| Type | IDs |
|---|---|
| Synonymous | 1110064L01Rik, AI647969, PDGF-C, SCDGF, VEGF-E |
| Gene |
UniProtKB-ID:
PDGFC_MOUSE
UniprotKB:
Q8CI19
UniParc:
UPI0000022D84
EMBL:
AF117608,
AK042767,
BC037696,
AF286725,
AF266467,
BC006027,
AK033734,
AK052947
Ensembl:
ENSMUSG00000028019
KO:
mmu:54635
|
| Nucleutide sequences |
EMBL-CDS:
BAC35216.1,
AAK58566.1,
BAC31358.1,
AAF91483.1,
AAH37696.1,
AAH06027.1,
AAF22516.1,
BAC28455.1
Ensembl_TRS:
ENSMUST00000029652
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000029652
RefSeq:
NP_001344675.1,
NP_064355.1
|
| Others |
UniRef100:
UniRef100_Q8CI19
UniRef90:
UniRef90_Q8CI19
UniRef50:
UniRef50_Q8CI19
UniGene:
Mm.331089
CCDS:
CCDS17425.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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