| Type | Description |
|---|---|
| Definition | Paf1, RNA polymerase II complex component |
| Date | Results | Publications |
|---|---|---|
| 2020-04-04 11:54:00 | Study shows that the Paf1 complex (Paf1C) modulates Pol II elongation rate, and loss of Paf1 results in accumulation of Ser5P in the first 20 to 30 kb of gene bodies, coinciding with reduction of histone H2B ubiquitylation specifically within this region. Moreover, reduced elongation rates provoked by Paf1 depletion resulted in defects in Pol II processivity and premature termination of transcription. | 31249142 |
| 2019-02-09 10:44:00 | ENL overcomes polycomb silencing through recruitment of PAF1 via the conserved YEATS domain, which recognizes acetylated histone H3. | 29217648 |
| 2016-05-14 11:49:00 | link Paf1C with PolII elongation and RNA processing indicates that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS)-proximal pA sites | 26765774 |
| 2013-12-21 10:35:00 | The PAF1 complex is required for mammalian development, likely through regulation of H3K36me3, indicating a functional conservation of the PAF1 complex from yeast to mammals in vivo. | 24036311 |
| 2013-08-31 12:04:00 | As part of a cell-intrinsic transcriptional pathway, Paf1 regulates neuronal migration in the brain. | 23791194 |
| Type | IDs |
|---|---|
| Synonymous | 5730511K23Rik, AA675045 |
| Gene |
UniProtKB-ID:
PAF1_MOUSE
UniprotKB:
Q8K2T8
UniParc:
UPI00000E7D26
EMBL:
AK134857,
BC083337,
AB041615,
AK148538,
AK017762,
BC029843
Ensembl:
ENSMUSG00000003437
KO:
mmu:54624
|
| Nucleutide sequences |
EMBL-CDS:
BAE22315.1,
BAB30913.1,
BAA95098.1,
BAE28608.1,
AAH83337.1,
AAH29843.1
Ensembl_TRS:
ENSMUST00000003529
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000003529
RefSeq:
NP_062331.2,
XP_036009151.1
|
| Others |
UniRef100:
UniRef100_Q8K2T8
UniRef90:
UniRef90_Q8N7H5
UniRef50:
UniRef50_Q8N7H5
UniGene:
Mm.7916
CCDS:
CCDS21043.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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