| Type | Description |
|---|---|
| Definition | POU class 5 homeobox 1B |
| Date | Results | Publications |
|---|---|---|
| 2020-01-25 10:39:00 | POU5F1B was underexpressed in AML compared with controls (P<0.001). The receiver operating characteristic (ROC) curve revealed that the POU5F1B transcript level was able to differentiate AML patients from healthy individuals (AUC=0.682). In non-APL AML patients. | 31271156 |
| 2019-05-11 12:12:00 | Radiotherapy contributed to the decline in the expression level of POU5F1B in plasma, which was upregulated in ECA109, ECA9706, KYSE410, and KYSE510, but not in HEEPIC. The knockdown of POU5F1B increased the radiosensitivity of esophageal cancer cell lines. | 30763293 |
| 2019-05-11 11:04:00 | POU5F1B was upregulated in cervical cancer and down-regulation inhibited cell proliferation and migration and induced apoptosis in cervical cancer cell lines by modulating OCT4. | 30762028 |
| 2018-10-13 11:29:00 | Study shows that irrespective of tumor type or clinicopathological status, breast cancer cells expressed high levels of Oct3/4 at mRNA and protein levels. Further sequencing analysis show that breast tumors and MCF-7 cell line predominantly expressed transcripts of POU5F1B, an Oct4-like gene from chromosome 8 which possess 94% similitude with oct-4. | 29620155 |
| 2018-09-01 11:09:00 | POU5F1B promotes hepatocellular carcinoma cell proliferation by activating AKT protein. | 29454285 |
| Type | IDs |
|---|---|
| Synonymous | OCT4-PG1, OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5F1P4, POU5FLC20, POU5FLC8 |
| Gene |
UniProtKB-ID:
P5F1B_HUMAN
UniprotKB:
Q06416
UniParc:
UPI000013F18B
EMBL:
GU480886,
HQ122782,
HQ122784,
GU480911,
HQ122870,
HQ122846,
GU480840,
HQ122868,
HQ122790,
HQ122710,
HQ122891,
HQ122869,
HQ122781,
HQ122879,
GU480883,
HQ122874,
HQ122892,
GU480896,
HQ122849,
HQ122878,
HQ122883,
HQ122721,
HQ122818,
HQ122884,
GU480835,
HQ122817,
AF268618,
GU480841,
HQ122824,
HQ122881,
HQ122823,
DQ120688,
HQ122787,
HQ122714,
HQ122886,
HQ122750,
HQ122786,
HQ122865,
HQ122848,
GU480845,
HQ122826,
GU480905,
GU480913,
HQ122885,
HQ122820,
HQ122822,
HQ122895,
HQ122788,
GU480842,
HQ122789,
GU480864,
HQ122711,
HQ122719,
GU480912,
HQ122867,
GU480868,
HQ122819,
HQ122882,
HQ122864,
GU480908,
HQ122855,
HQ122900,
HQ122785,
HQ122898,
HQ122887,
HQ122713,
HQ122751,
HQ122877,
HQ122902,
HQ122871,
HQ122903,
HQ122716,
HQ122866,
DQ486513,
HQ122843,
AC016883,
HQ122816,
HQ122827,
HQ122749,
HQ122853,
HQ122893,
HQ122851,
GU480880,
GU480878,
HQ122854,
HQ122845,
AF268615,
HQ122876,
HQ122752,
HQ122712,
HQ122844,
GU480906,
HQ122880,
HQ122852,
HQ122842,
GU480902,
HQ122841,
HQ122718,
Z11901,
HQ122783,
HQ122717,
HQ122825,
GU480889,
HQ122857,
HQ122856,
HQ122821
Ensembl:
ENSG00000212993
KO:
hsa:5462
|
| Nucleutide sequences |
EMBL-CDS:
ADW77479.1,
ADW77500.1,
ADE48614.1,
AAG53083.1,
ADW77491.1,
ADW77477.1,
ADW77515.1,
ADW77444.1,
ADW77497.1,
ADW77360.1,
ADW77359.1,
ADW77417.1,
ADW77450.1,
ADW77476.1,
ADW77478.1,
ADW77514.1,
ADW77388.1,
ADE48597.1,
ADE48568.1,
ADW77446.1,
ADW77421.1,
ADW77489.1,
ADW77511.1,
ADE48599.1,
ADW77480.1,
ADW77503.1,
ADW77467.1,
ADW77386.1,
ADW77475.1,
ADE48567.1,
AAG53085.1,
ADW77354.1,
ADW77447.1,
ADW77358.1,
ADE48561.1,
ADW77351.1,
ADW77517.1,
ADW77495.1,
ADW77513.1,
ADW77468.1,
ADW77415.1,
ADW77490.1,
ADW77492.1,
ADW77416.1,
ADE48580.1,
ADW77502.1,
ADW77451.1,
ABF29403.1,
ADE48591.1,
ADW77507.1,
ADW77505.1,
ADW77353.1,
ADW77387.1,
ADE48615.1,
ADW77472.1,
ADE48610.1,
ADW77471.1,
ADE48612.1,
ADW77449.1,
ADW77473.1,
ADW77419.1,
ADW77499.1,
ADE48609.1,
ADW77356.1,
ADW77357.1,
ADE48604.1,
ADW77469.1,
ADW77501.1,
ADW77422.1,
ADW77453.1,
ADW77385.1,
ADW77496.1,
ADE48583.1,
ADE48606.1,
ADW77488.1,
ADW77516.1,
ADW77506.1,
ADW77481.1,
ADW77518.1,
ADE48566.1,
ADW77512.1,
ADW77418.1,
ADE48593.1,
CAA77953.1,
ADW77352.1,
ADE48596.1,
ADW77452.1,
ADW77487.1,
ADW77424.1,
ADW77504.1,
ADW77494.1,
ADW77445.1,
ADW77498.1,
ADW77493.1,
ADE48616.1,
ADW77423.1,
ADW77470.1,
ADW77474.1,
ADW77448.1,
ABB92462.1,
ADW77455.1,
ADW77454.1,
ADW77420.1,
ADE48570.1,
ADW77355.1
Ensembl_TRS:
ENST00000465342,
ENST00000645438
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000419298,
ENSP00000495779
RefSeq:
NP_001153014.1
|
| Others |
UniRef100:
UniRef100_Q06416
UniRef90:
UniRef90_Q06416
UniRef50:
UniRef50_Q06416
UniGene:
Hs.450254
CCDS:
CCDS55274.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
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