| Type | Description |
|---|---|
| Definition | ubiquilin 2 |
| Date | Results | Publications |
|---|---|---|
| 2019-12-21 11:41:00 | extra UBQLN2 proteins can exacerbate cytoplasmic TDP-43 accumulations by competing with the UPS for binding to ubiquitin. | 30377984 |
| 2018-03-31 10:50:00 | Results have shown that the two P497S and P506T mutant UBQLN2 Tg mouse lines recapitulate the central features of ALS with frontotemporal dementia (ALS-FTD) found in humans and indicate that these mutant UBQLN2 mice with end stage of disease display a reduction of TDP-43 staining in the nucleus with concomitant formation of cytoplasmic ubiquitin+ inclusions in spinal motor neurons. | 27834214 |
| 2016-12-17 10:50:00 | UBQLN2 most evidently bound to HSP70-type chaperones, UBQLN1 and UBQLN4 and to a lesser extent to proteasomal subunits; UBQLN2 may be involved in the regulation of misfolded proteins. Mutations in UBQLN2, which lead to neurodegeneration in humans, are defective in chaperone binding, impair aggregate clearance, and cause cognitive deficits in mice. | 27477512 |
| 2016-08-27 12:49:00 | Results showed that UBQLN2 is selectively recruited to nuclear inclusions in Huntington's disease but not spinocerebellar ataxia type 3 | 26141599 |
| 2016-07-16 10:46:00 | UBQLN2 dysregulation in neurons can drive NF-kappaB activation and cytosolic TDP-43 aggregation. | 26521126 |
| Type | IDs |
|---|---|
| Synonymous | Chap1, Dsk2, HRIHFB2157, Plic-2, Plic2 |
| Gene |
UniProtKB-ID:
UBQL2_MOUSE
UniprotKB:
Q9QZM0
UniParc:
UPI0000195EB2
EMBL:
CH466653,
AL844583,
AF177346,
BC021824,
BC053022
Ensembl:
ENSMUSG00000050148
KO:
mmu:54609
|
| Nucleutide sequences |
EMBL-CDS:
AAH21824.1,
AAF01366.1,
EDL31351.1,
AAH53022.1
Ensembl_TRS:
ENSMUST00000060714
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000056888
RefSeq:
NP_061268.2
|
| Others |
UniRef100:
UniRef100_Q9QZM0
UniRef90:
UniRef90_Q9QZM0
UniRef50:
UniRef50_Q9UHD9
UniGene:
Mm.430772
CCDS:
CCDS30482.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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