| Type | Description |
|---|---|
| Definition | suppressor of cytokine signaling 6 |
| Date | Results | Publications |
|---|---|---|
| 2018-02-03 10:59:00 | Results suggest: 1) SOCS6 and SOCS7 bind tyrosine-phosphorylated DAB1 and commit it to ubiquitination and proteasomal degradation. 2) Removal of phosphorylated DAB1 by SOCS6 and SOCS7 terminates reelin signaling and allows a new cycle of reelin signaling to commence. 3) Repeated cycles of reelin signaling "ON" and "OFF" drive the fundamentally cyclic process of cell migration in the cortex. | 26503265 |
| 2014-09-20 12:01:00 | Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6 | 24284072 |
| 2010-01-21 00:00:00 | SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation(SOCS-6) | 12052866 |
| 2010-01-21 00:00:00 | TH1-specific chromatin structure is created by early recruitment of Swi-SNF complexes and nucleosome remodeling dependent on Stat4. | 16717115 |
| 2010-01-21 00:00:00 | SOCS-6 expression is induced by insulin, which regulates its binding to the p85 monomer of phosphoinositide 3-kinase | 15123678 |
| Type | IDs |
|---|---|
| Synonymous | 1500012M23Rik, 5830401B18Rik, AI447482, Cis4, Cish4, HSPC060, SOCS-4, SOCS-6, SSI4, STAI4, STATI4, Socs4 |
| Gene |
UniProtKB-ID:
SOCS6_MOUSE
UniprotKB:
Q9JLY0
UniParc:
UPI0000028E77
EMBL:
AK031164,
CH466632,
AK156591,
AK019993,
AK142069,
AK044946,
BC094443,
BC017597,
AF121907,
AK028665,
AK028701
Ensembl:
ENSMUSG00000056153
KO:
mmu:54607
|
| Nucleutide sequences |
EMBL-CDS:
BAE33770.1,
EDL00645.1,
AAH94443.1,
BAC26055.1,
BAC26074.1,
BAC32154.1,
EDL00646.1,
AAH17597.1,
AAF28872.1,
BAC27287.1,
BAE24930.1,
BAB31956.1
Ensembl_TRS:
ENSMUST00000125362,
ENSMUST00000123826,
ENSMUST00000070116
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000118764,
ENSMUSP00000114993,
ENSMUSP00000064929
RefSeq:
XP_006526576.1,
XP_030106401.1,
XP_011245392.1,
XP_011245391.1,
NP_061291.2
|
| Others |
UniRef100:
UniRef100_Q9JLY0
UniRef90:
UniRef90_Q9JLY0
UniRef50:
UniRef50_O14544
UniGene:
Mm.91920,
Mm.476577
CCDS:
CCDS29389.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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