| Type | Description |
|---|---|
| Definition | LINE1 type transposase domain containing 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 13:04:00 | Study results identify increased expression of L1TD1 as a prognostic marker predicting longer disease-free survival in colon cancer patients. | 31337362 |
| 2019-06-29 11:23:00 | this study shows that LINE1 contributes to autoimmunity through both RIG-I- and MDA5-mediated RNA sensing pathways | 29525183 |
| 2019-04-20 11:45:00 | The authors propose a model in which RNase H2 degrades the LINE-1 RNA after reverse transcription, allowing retrotransposition to be completed. This also explains how LINE-1 elements can retrotranspose efficiently without their own RNase H activity. | 29959219 |
| 2017-07-29 13:08:00 | and L1TD1 are tumor-specifically methylated in NSCLCs and that DNA methylation is involved in the transcriptional regulation of these genes. Moreover, in vitro as well as in vivo experiments revealed tumor-cell growth suppressing properties of L1TD1 in NSCLC cells. | 28093071 |
| 2016-08-27 11:44:00 | L1TD1 depletion reduced medulloblastoma cell viability, cell proliferation, downregulated expression of the neural stem cell markers and induced apoptosis. | 26159230 |
| Type | IDs |
|---|---|
| Synonymous | ECAT11 |
| Gene |
UniProtKB-ID:
LITD1_HUMAN
UniprotKB:
Q5T7N2
UniParc:
UPI000013E18E
EMBL:
AK001746,
AL834314,
AB211065,
AK001973,
AL162739,
BC111559
Ensembl:
ENSG00000240563
KO:
hsa:54596
|
| Nucleutide sequences |
EMBL-CDS:
AAI11560.1,
BAA92011.1,
BAA91878.1,
BAD95492.1,
CAD38984.1
Ensembl_TRS:
ENST00000498273
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000419901
RefSeq:
NP_061952.3,
NP_001158307.1
|
| Others |
UniRef100:
UniRef100_Q5T7N2
UniRef90:
UniRef90_Q5T7N2
UniRef50:
UniRef50_Q5T7N2
UniGene:
Hs.685462
CCDS:
CCDS619.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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