| Type | Description |
|---|---|
| Definition | inhibitor of growth family member 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:11:00 | Downregulation of nuclear ING3 expression and translocalization to cytoplasm promotes tumorigenesis and progression in head and neck squamous cell carcinoma (HNSCC). | 31886514 |
| 2021-01-09 13:28:00 | Nuclear localization of ING3 is required to suppress melanoma cell migration, invasion and angiogenesis. | 32334834 |
| 2020-09-12 15:59:00 | ING3 is required for ATM signaling and DNA repair in response to DNA double strand breaks. | 30804473 |
| 2019-01-26 12:40:00 | Data show that ING3 associates with gene promoters to regulate a transcriptional network that is required for cellular proliferation. Importantly, ING3 elevated copy number and protein levels in cancer patients, particularly in treatment-resistant patients, designate ING3 as a novel marker of poor survival for cancer patients and an unsuspected oncoprotein. | 29381681 |
| 2017-05-13 19:38:00 | results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities. | 27281824 |
| Type | IDs |
|---|---|
| Synonymous | Eaf4, ING2, MEAF4, p47ING3 |
| Gene |
UniProtKB-ID:
ING3_HUMAN,
B7ZKQ7_HUMAN
UniprotKB:
Q9NXR8,
B7ZKQ7
UniParc:
UPI00000373B3,
UPI00001A3E5F,
UPI000020F9B2,
UPI00000712F6
EMBL:
BC143316,
BC101609,
AF161419,
BC073865,
AK291905,
AL603623,
AC004537,
BC009777,
AK000096,
BC062634,
BC093091,
BC010851,
AY007790,
AF074968,
BC093689
Ensembl:
ENSG00000071243
KO:
hsa:54556
|
| Nucleutide sequences |
EMBL-CDS:
AAH73865.1,
BAF84594.1,
AAF28979.1,
AAQ93373.1,
AAG23285.1,
AAH62634.1,
AAG12172.1,
AAH10851.1,
BAA90942.1,
AAH93689.1,
AAH93091.1,
AAQ93374.1,
CAC48260.2,
AAH09777.1,
AAH09776.1,
AAI01610.1,
AAI43317.1
Gene_ORFName:
HSPC301
Ensembl_TRS:
ENST00000427726,
ENST00000315870,
ENST00000339121
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000410406,
ENSP00000320566,
ENSP00000341697
RefSeq:
NP_938008.1,
XP_016867858.1,
NP_061944.2
|
| Others |
UniRef100:
UniRef100_Q9NXR8,
UniRef100_B7ZKQ7
UniRef90:
UniRef90_Q9NXR8,
UniRef90_A0A2K5VMI0
UniRef50:
UniRef50_Q9NXR8,
UniRef50_A0A0C4DG38
UniGene:
Hs.489811
CCDS:
CCDS35497.1,
CCDS5778.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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