| Type | Description |
|---|---|
| Definition | ring finger protein 186 |
| Date | Results | Publications |
|---|---|---|
| 2021-04-03 13:35:00 | The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function. | 32486221 |
| 2020-06-13 13:07:00 | RNF186 and Sestrin-2 bind each other through distinct C-terminal motifs and that Lys-13 in Sestrin-2 is a putative ubiquitin acceptor site. RNF186 knockdown increased Sestrin-2 protein levels and decreased mTORC1 activation. | 31586034 |
| 2018-09-08 12:04:00 | a predicted protein-truncating variant (rs36095412, p.R179X, genotyped in 11,148 ulcerative colitis patients and 295,446 controls, MAF=up to 0.78%) in RNF186, a single-exon ring finger E3 ligase with strong colonic expression, protects against ulcerative colitis. | 27503255 |
| 2014-03-22 11:05:00 | Our results confirmed significant association to rare non-synonymous coding variants in both IL23R and CARD9, previously identified from sequencing of CD loci, as well as identified a novel association in RNF186 | 24068945 |
| 2014-03-22 10:29:00 | BNip1 functions as a downstream modulator of RNF186 to direct endoplasmic reticulum stress-associated apoptotic signaling. | 23896122 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
RN186_HUMAN
UniprotKB:
Q9NXI6
UniParc:
UPI0000073BA5
EMBL:
AK000232,
AL391883,
BC030960,
CR457228,
BC051880,
AK222991
Ensembl:
ENSG00000178828
KO:
hsa:54546
|
| Nucleutide sequences |
EMBL-CDS:
BAA91024.1,
AAH30960.1,
CAG33509.1,
AAH51880.1,
BAD96711.1
Ensembl_TRS:
ENST00000375121
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364263
RefSeq:
NP_061935.1
|
| Others |
UniRef100:
UniRef100_Q9NXI6
UniRef90:
UniRef90_Q9NXI6
UniRef50:
UniRef50_Q9NXI6
UniGene:
Hs.124835
CCDS:
CCDS199.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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