The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function.

Int J Mol Sci     Takumi Okamoto , Kazunori Imaizumi , Masayuki Kaneko

A reference map of the human binary protein interactome.

Nature     Katja Luck , Dae-Kyum Kim , Luke Lambourne , Kerstin Spirohn , Bridget E Begg , Wenting Bian , Ruth Brignall , Tiziana Cafarelli , Francisco J Campos-Laborie , Benoit Charloteaux , Dongsic Choi , Atina G Coté , Meaghan Daley , Steven Deimling , Alice Desbuleux , Amélie Dricot , Marinella Gebbia , Madeleine F Hardy , Nishka Kishore , Jennifer J Knapp , István A Kovács , Irma Lemmens , Miles W Mee , Joseph C Mellor , Carl Pollis , Carles Pons , Aaron D Richardson , Sadie Schlabach , Bridget Teeking , Anupama Yadav , Mariana Babor , Dawit Balcha , Omer Basha , Christian Bowman-Colin , Suet-Feung Chin , Soon Gang Choi , Claudia Colabella , Georges Coppin , Cassandra D'Amata , David De Ridder , Steffi De Rouck , Miquel Duran-Frigola , Hanane Ennajdaoui , Florian Goebels , Liana Goehring , Anjali Gopal , Ghazal Haddad , Elodie Hatchi , Mohamed Helmy , Yves Jacob , Yoseph Kassa , Serena Landini , Roujia Li , Natascha van Lieshout , Andrew MacWilliams , Dylan Markey , Joseph N Paulson , Sudharshan Rangarajan , John Rasla , Ashyad Rayhan , Thomas Rolland , Adriana San-Miguel , Yun Shen , Dayag Sheykhkarimli , Gloria M Sheynkman , Eyal Simonovsky , Murat Taşan , Alexander Tejeda , Vincent Tropepe , Jean-Claude Twizere , Yang Wang , Robert J Weatheritt , Jochen Weile , Yu Xia , Xinping Yang , Esti Yeger-Lotem , Quan Zhong , Patrick Aloy , Gary D Bader , Javier De Las Rivas , Suzanne Gaudet , Tong Hao , Janusz Rak , Jan Tavernier , David E Hill , Marc Vidal , Frederick P Roth , Michael A Calderwood

The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing.

J Biol Chem     Travis B Lear , Karina C Lockwood , Yurong Ouyang , John W Evankovich , Mads B Larsen , Bo Lin , Yuan Liu , Bill B Chen

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.

Cell Rep     Sathish Kumar , Rina Barouch-Bentov , Fei Xiao , Stanford Schor , Szuyuan Pu , Elise Biquand , Albert Lu , Brett D Lindenbach , Yves Jacob , Caroline Demeret , Shirit Einav

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Nat Commun     Manuel A Rivas , Daniel Graham , Patrick Sulem , Christine Stevens , A Nicole Desch , Philippe Goyette , Daniel Gudbjartsson , Ingileif Jonsdottir , Unnur Thorsteinsdottir , Frauke Degenhardt , Sören Mucha , Mitja I Kurki , Dalin Li , Mauro D'Amato , Vito Annese , Severine Vermeire , Rinse K Weersma , Jonas Halfvarson , Paulina Paavola-Sakki , Maarit Lappalainen , Monkol Lek , Beryl Cummings , Taru Tukiainen , Talin Haritunians , Leena Halme , Lotta L E Koskinen , Ashwin N Ananthakrishnan , Yang Luo , Graham A Heap , Marijn C Visschedijk , UK IBD Genetics Consortium , NIDDK IBD Genetics Consortium , Daniel G MacArthur , Benjamin M Neale , Tariq Ahmad , Carl A Anderson , Steven R Brant , Richard H Duerr , Mark S Silverberg , Judy H Cho , Aarno Palotie , Päivi Saavalainen , Kimmo Kontula , Martti Färkkilä , Dermot P B McGovern , Andre Franke , Kari Stefansson , John D Rioux , Ramnik J Xavier , Mark J Daly , J Barrett , K de Lane , C Edwards , A Hart , C Hawkey , L Jostins , N Kennedy , C Lamb , J Lee , C Lees , J Mansfield , C Mathew , C Mowatt , B Newman , E Nimmo , M Parkes , M Pollard , N Prescott , J Randall , D Rice , J Satsangi , A Simmons , M Tremelling , H Uhlig , D Wilson , C Abraham , J P Achkar , A Bitton , G Boucher , K Croitoru , P Fleshner , J Glas , S Kugathasan , J V Limbergen , R Milgrom , D Proctor , M Regueiro , P L Schumm , Y Sharma , J M Stempak , S R Targan , M H Wang

A novel RING finger E3 ligase RNF186 regulate ER stress-mediated apoptosis through interaction with BNip1.

Cell. Signal.     Peng Wang , Yanfang Wu , Yan Li , Jiyan Zheng , Jie Tang

Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.

Inflamm. Bowel Dis.     Suk-Kyun Yang , Myunghee Hong , Wanting Zhao , Yusun Jung , Naeimeh Tayebi , Byong Duk Ye , Kyung-Jo Kim , Sang Hyoung Park , Inchul Lee , Hyoung Doo Shin , Hyun Sub Cheong , Lyoung Hyo Kim , Hyo-Jong Kim , Sung-Ae Jung , Daehee Kang , Hee-Shang Youn , Jianjun Liu , Kyuyoung Song

Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis.

PLoS Genet     Mélissa Beaudoin , Philippe Goyette , Gabrielle Boucher , Ken Sin Lo , Manuel A Rivas , Christine Stevens , Azadeh Alikashani , Martin Ladouceur , David Ellinghaus , Leif Törkvist , Gautam Goel , Caroline Lagacé , Vito Annese , Alain Bitton , Jakob Begun , Steve R Brant , Francesca Bresso , Judy H Cho , Richard H Duerr , Jonas Halfvarson , Dermot P B McGovern , Graham Radford-Smith , Stefan Schreiber , Philip L Schumm , Yashoda Sharma , Mark S Silverberg , Rinse K Weersma , Quebec IBD Genetics Consortium , NIDDK IBD Genetics Consortium , International IBD Genetics Consortium , Mauro D'Amato , Severine Vermeire , Andre Franke , Guillaume Lettre , Ramnik J Xavier , Mark J Daly , John D Rioux

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.

Brief. Bioinformatics     Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas

Genome-wide association identifies multiple ulcerative colitis susceptibility loci.

Nat. Genet.     Dermot P B McGovern , Agnès Gardet , Leif Törkvist , Philippe Goyette , Jonah Essers , Kent D Taylor , Benjamin M Neale , Rick T H Ong , Caroline Lagacé , Chun Li , Todd Green , Christine R Stevens , Claudine Beauchamp , Phillip R Fleshner , Marie Carlson , Mauro D'Amato , Jonas Halfvarson , Martin L Hibberd , Mikael Lördal , Leonid Padyukov , Angelo Andriulli , Elisabetta Colombo , Anna Latiano , Orazio Palmieri , Edmond-Jean Bernard , Colette Deslandres , Daan W Hommes , Dirk J de Jong , Pieter C Stokkers , Rinse K Weersma , NIDDK IBD Genetics Consortium , Yashoda Sharma , Mark S Silverberg , Judy H Cho , Jing Wu , Kathryn Roeder , Steven R Brant , L Phillip Schumm , Richard H Duerr , Marla C Dubinsky , Nicole L Glazer , Talin Haritunians , Andy Ippoliti , Gil Y Melmed , David S Siscovick , Eric A Vasiliauskas , Stephan R Targan , Vito Annese , Cisca Wijmenga , Sven Pettersson , Jerome I Rotter , Ramnik J Xavier , Mark J Daly , John D Rioux , Mark Seielstad