Type | Description |
---|---|
Definition | heparanase 2 |
Date | Results | Publications |
---|---|---|
2020-04-04 11:43:00 | Mice with homozygous mutations in either Lrig2 or Hpse2 had increased nerve density within the urinary bladder body and decreased nerve density around the urinary outflow tract. Observations provide evidence that a peripheral neuropathy is central to the pathobiology of functional bladder outlet obstruction in urofacial syndrome and emphasize the importance of LRIG2 and Hpse2 for nerve patterning in the urinary tract. | 30885509 |
2016-01-16 11:12:00 | Deletion of Hpse2 cause the urofacial syndrome-like phenotype in mice. | 25510506 |
Type | IDs |
---|---|
Synonymous | Gm968, Hpa2 |
Gene |
UniProtKB-ID:
HPSE2_MOUSE
UniprotKB:
B2RY83
UniParc:
UPI0000434F43
EMBL:
BC158136,
AC125458,
BC158133,
AC126795,
AC124716,
BC158131,
AC122312,
AC140375
Ensembl:
ENSMUSG00000074852
KO:
mmu:545291
|
Nucleutide sequences |
EMBL-CDS:
AAI58132.1,
AAI58134.1,
AAI58137.1
Ensembl_TRS:
ENSMUST00000099428
|
Protein sequencees |
Ensembl_PRO:
ENSMUSP00000097026
RefSeq:
XP_011245596.1,
XP_011245597.1,
XP_006527277.1,
NP_001074726.1
|
Others |
UniRef100:
UniRef100_B2RY83
UniRef90:
UniRef90_B2RY83
UniRef50:
UniRef50_B2RY83
UniGene:
Mm.442200
CCDS:
CCDS37993.1
|
{{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
---|---|---|---|---|---|---|---|---|
Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
暂无数据
Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
---|---|---|---|
30885509 |
Lrig2 and Hpse2, mutated in urofacial syndrome, pattern nerves in the urinary bladder. Kidney Int Neil A Roberts , Emma N Hilton , Filipa M Lopes , Subir Singh , Michael J Randles , Natalie J Gardiner , Karl Chopra , Riccardo Coletta , Zunera Bajwa , Robert J Hall , Wyatt W Yue , Franz Schaefer , Stefanie Weber , Roger Henriksson , Helen M Stuart , HÃ¥kan Hedman , William G Newman , Adrian S Woolf |
2019-05-01 | - |
25510506 |
A mouse model of urofacial syndrome with dysfunctional urination. Hum. Mol. Genet. Chunming Guo , Satoshi Kaneko , Ye Sun , Yichen Huang , Israel Vlodavsky , Xiaokun Li , Zhong-Rong Li , Xue Li |
2015-04-01 |
Hpse2
|
25145936 |
Urinary tract effects of HPSE2 mutations. J. Am. Soc. Nephrol. Helen M Stuart , Neil A Roberts , Emma N Hilton , Edward A McKenzie , Sarah B Daly , Kristen D Hadfield , Jeffery S Rahal , Natalie J Gardiner , Simon W Tanley , Malcolm A Lewis , Emily Sites , Brad Angle , Cláudia Alves , Teresa Lourenço , Márcia Rodrigues , Angelina Calado , Marta Amado , Nancy Guerreiro , Inês Serras , Christian Beetz , Rita-Eva Varga , Mesrur Selcuk Silay , John M Darlow , Mark G Dobson , David E Barton , Manuela Hunziker , Prem Puri , Sally A Feather , Judith A Goodship , Timothy H J Goodship , Heather J Lambert , Heather J Cordell , UK VUR Study Group , Anand Saggar , Maria Kinali , 4C Study Group , Christian Lorenz , Kristina Moeller , Franz Schaefer , Aysun K Bayazit , Stefanie Weber , William G Newman , Adrian S Woolf |
2015-04-01 |
HPSE2
|
21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
20560210 |
Mutations in HPSE2 cause urofacial syndrome. Am. J. Hum. Genet. Sarah B Daly , Jill E Urquhart , Emma Hilton , Edward A McKenzie , Richard A Kammerer , Malcolm Lewis , Bronwyn Kerr , Helen Stuart , Dian Donnai , David A Long , Berk Burgu , Ozgu Aydogdu , Murat Derbent , Sixto Garcia-Minaur , Willie Reardon , Blanca Gener , Stavit Shalev , Rupert Smith , Adrian S Woolf , Graeme C Black , William G Newman |
2010-06-11 | - |
16141072 |
The transcriptional landscape of the mammalian genome. Science P Carninci , T Kasukawa , S Katayama , J Gough , M C Frith , N Maeda , R Oyama , T Ravasi , B Lenhard , C Wells , R Kodzius , K Shimokawa , V B Bajic , S E Brenner , S Batalov , A R R Forrest , M Zavolan , M J Davis , L G Wilming , V Aidinis , J E Allen , A Ambesi-Impiombato , R Apweiler , R N Aturaliya , T L Bailey , M Bansal , L Baxter , K W Beisel , T Bersano , H Bono , A M Chalk , K P Chiu , V Choudhary , A Christoffels , D R Clutterbuck , M L Crowe , E Dalla , B P Dalrymple , B de Bono , G Della Gatta , D di Bernardo , T Down , P Engstrom , M Fagiolini , G Faulkner , C F Fletcher , T Fukushima , M Furuno , S Futaki , M Gariboldi , P Georgii-Hemming , T R Gingeras , T Gojobori , R E Green , S Gustincich , M Harbers , Y Hayashi , T K Hensch , N Hirokawa , D Hill , L Huminiecki , M Iacono , K Ikeo , A Iwama , T Ishikawa , M Jakt , A Kanapin , M Katoh , Y Kawasawa , J Kelso , H Kitamura , H Kitano , G Kollias , S P T Krishnan , A Kruger , S K Kummerfeld , I V Kurochkin , L F Lareau , D Lazarevic , L Lipovich , J Liu , S Liuni , S McWilliam , M Madan Babu , M Madera , L Marchionni , H Matsuda , S Matsuzawa , H Miki , F Mignone , S Miyake , K Morris , S Mottagui-Tabar , N Mulder , N Nakano , H Nakauchi , P Ng , R Nilsson , S Nishiguchi , S Nishikawa , F Nori , O Ohara , Y Okazaki , V Orlando , K C Pang , W J Pavan , G Pavesi , G Pesole , N Petrovsky , S Piazza , J Reed , J F Reid , B Z Ring , M Ringwald , B Rost , Y Ruan , S L Salzberg , A Sandelin , C Schneider , C Schönbach , K Sekiguchi , C A M Semple , S Seno , L Sessa , Y Sheng , Y Shibata , H Shimada , K Shimada , D Silva , B Sinclair , S Sperling , E Stupka , K Sugiura , R Sultana , Y Takenaka , K Taki , K Tammoja , S L Tan , S Tang , M S Taylor , J Tegner , S A Teichmann , H R Ueda , E van Nimwegen , R Verardo , C L Wei , K Yagi , H Yamanishi , E Zabarovsky , S Zhu , A Zimmer , W Hide , C Bult , S M Grimmond , R D Teasdale , E T Liu , V Brusic , J Quackenbush , C Wahlestedt , J S Mattick , D A Hume , C Kai , D Sasaki , Y Tomaru , S Fukuda , M Kanamori-Katayama , M Suzuki , J Aoki , T Arakawa , J Iida , K Imamura , M Itoh , T Kato , H Kawaji , N Kawagashira , T Kawashima , M Kojima , S Kondo , H Konno , K Nakano , N Ninomiya , T Nishio , M Okada , C Plessy , K Shibata , T Shiraki , S Suzuki , M Tagami , K Waki , A Watahiki , Y Okamura-Oho , H Suzuki , J Kawai , Y Hayashizaki , FANTOM Consortium , RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) |
2005-09-02 | - |
16141073 |
Antisense transcription in the mammalian transcriptome. Science S Katayama , Y Tomaru , T Kasukawa , K Waki , M Nakanishi , M Nakamura , H Nishida , C C Yap , M Suzuki , J Kawai , H Suzuki , P Carninci , Y Hayashizaki , C Wells , M Frith , T Ravasi , K C Pang , J Hallinan , J Mattick , D A Hume , L Lipovich , S Batalov , P G Engström , Y Mizuno , M A Faghihi , A Sandelin , A M Chalk , S Mottagui-Tabar , Z Liang , B Lenhard , C Wahlestedt , RIKEN Genome Exploration Research Group , Genome Science Group (Genome Network Project Core Group) , FANTOM Consortium |
2005-09-02 |
Gm14018,
Gm14964,
F630206G17Rik,
Oog3,
Notumos,
Ldlrap1,
Mdn1,
Pydc3,
9330171B17Rik,
Mfap1b,
Tmsb15b2,
Gm12802,
E430020m11rik,
Gm11335,
Gm15772,
Gm17762,
A930017K11Rik,
LOC100036513,
Gata5os,
Umad1,
Gm16982,
Gm9887,
Gm9872,
LOC100036530,
Gm9934,
Gm9913,
Gm11149,
BC028777,
Gm13999,
LOC100036540,
Gm9744,
Gm9983,
D630002J18Rik,
Gm16525,
Gm11696,
Dnajc3,
9430060I03Rik,
Gm12359,
4921516A02Rik,
Fam129c,
Gm10589,
Rsph3b,
Rnaset2a,
5430403G19Rik,
D030047H15Rik,
Gm13274,
B930046K06Rik,
Gm10862,
Gm10792,
Gm10802,
Gm10532,
G730003C15Rik,
Runx2os1,
Gm15612,
Gm10856,
Gm10857,
Gm10685,
Gm10803,
Gm10723,
F630028O10Rik,
Gm10836,
Gm10405,
Gm10513,
Gm10609,
F630201L12Rik,
4932427H20Rik,
Zfp389,
Gm10763,
Gm10062,
Gm10714,
Gm10531,
Gm10876,
Gm10750,
Gm10433,
Gm10837,
Gm10647,
Gm10648,
Gm10650,
Gm10610,
F830115B05Rik,
Gm10473,
Gm10614,
Gm10286,
G730046D07Rik,
Gm10287,
Gm10785,
Gm10183,
Gm10512,
1700061E17Rik,
Gm44113,
Gm10579,
Gm10741,
Gm10827,
Gm10522,
Gm10536,
Gm15998,
Faddos,
D130050E23Rik,
Gm10735
|
14691545 |
Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. Alexei A Sharov , Yulan Piao , Ryo Matoba , Dawood B Dudekula , Yong Qian , Vincent VanBuren , Geppino Falco , Patrick R Martin , Carole A Stagg , Uwem C Bassey , Yuxia Wang , Mark G Carter , Toshio Hamatani , Kazuhiro Aiba , Hidenori Akutsu , Lioudmila Sharova , Tetsuya S Tanaka , Wendy L Kimber , Toshiyuki Yoshikawa , Saied A Jaradat , Serafino Pantano , Ramaiah Nagaraja , Kenneth R Boheler , Dennis Taub , Richard J Hodes , Dan L Longo , David Schlessinger , Jonathan Keller , Emily Klotz , Garnett Kelsoe , Akihiro Umezawa , Angelo L Vescovi , Janet Rossant , Tilo Kunath , Brigid L M Hogan , Anna Curci , Michele D'Urso , Janet Kelso , Winston Hide , Minoru S H Ko |
2003-12-01 |
Mdn1,
E330027M22Rik,
Gm16508,
Gm10859,
Gm14661,
Gm3139,
Gm3286,
Gm13247,
Gm10210,
Gm14243,
Gpn2,
Btbd18,
AA543401,
Gm19552,
Zfp648,
Tmppe,
Gm11239,
LOC101056073,
Adamts9,
Hinfp,
Halr1,
Itga9,
Cabin1,
Chrf,
Abhd4,
Acaca,
Lgr4,
Tm6sf1,
H2-Q9,
Slc18a1,
Abca1,
Abl1,
Alppl2,
Aldoa,
Birc5,
Arf1,
Slc7a2,
Birc6,
Cacna1g,
Cacnb3,
Aspm,
Capn3,
Capn6,
Rb1cc1,
Cdh6,
Cdk2,
Cfi,
Cntn1,
Col10a1,
Col4a5,
Col6a3,
Cox7a2,
Cxadr,
Dcc,
Asap1,
Dhx9,
Dst,
Ect2,
Ednra,
Efna1,
Rhbdf1,
Eif1a,
Eif4e,
Eif4g2,
Emd,
Epha7,
Ube4a,
Ms4a2,
Fgd1,
Foxn2,
Fmo5,
Fn1,
Srgap2,
Frk,
Gfpt1,
Gpc4,
Lpcat3,
Nr3c1,
Hp1bp3,
Hpn,
Dnaja1,
Hspg2,
Elavl4,
Ikbkg,
Lrig1,
Itch,
Itga7,
Itpr1,
Kif16b,
Lama5,
Ldb2,
Lepr,
Zscan5b,
Glcci1,
Usp33,
Slc26a6,
Mdm2,
Cd200,
Mpo
|
14610273 |
Proc. Natl. Acad. Sci. U.S.A. Brian P Zambrowicz , Alejandro Abuin , Ramiro Ramirez-Solis , Lizabeth J Richter , James Piggott , Hector BeltrandelRio , Eric C Buxton , Joel Edwards , Rick A Finch , Carl J Friddle , Anupma Gupta , Gwenn Hansen , Yi Hu , Wenhu Huang , Crystal Jaing , Billie Wayne Key , Peter Kipp , Buckley Kohlhauff , Zhi-Qing Ma , Diane Markesich , Robert Payne , David G Potter , Ny Qian , Joseph Shaw , Jeff Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Isaac Van Sligtenhorst , Peter Vogel , Wade Walke , Nianhua Xu , Qichao Zhu , Christophe Person , Arthur T Sands |
2003-11-25 |
Gm14018,
Notumos,
Ldlrap1,
Mdn1,
Gm11335,
Rps12-ps4,
Gm17762,
Umad1,
BC028777,
Gm13999,
Gm9744,
Gm11696,
Dnajc3,
Rsph3b,
D030047H15Rik,
Gm10685,
Gm10876,
Gm10433,
Gm10706,
Gm15441,
Gm10787,
Apela,
Gm10640,
Dnmt3aos,
Gm10822,
Gm10687,
Gm10658,
Gm11744,
Gm10848,
Gm10535,
F420014N23Rik,
Gm16287,
Gm10463,
Fmr1os,
Gm12298,
Tmem51os1,
Gm14488,
Gm15401,
Gm10209,
Gm1976,
Gm1974,
Gm1998,
Gm13552,
Gm10031,
Gm20796,
Gm11496,
Gm2022,
Gm2050,
Gm2058,
Gm13580,
Gm2085,
Gm2087,
Gm2137,
Rps16-ps2,
Gm2183,
Gm2225,
B230206L02Rik,
Gm15706,
Gm2294,
Gm2295,
Gm2297,
Tbx3os1,
Gm2312,
Gm2315,
Gm2329,
Gm10320,
Lncenc1,
Gm2379,
Gm2381,
Gm12168,
Gm2419,
Hrct1,
Gm2428,
D5Ertd605e,
Gm2434,
Gm16020,
Gm2443,
Gm2450,
Gm2456,
Snhg12,
Gm2479,
Gm13022,
Gm2494,
Gm12184,
Gm2529,
Gm2530,
Gm2582,
Gm12193,
Gm2603,
Gm2650,
Rsf1os2,
Gm2667,
Gm13182,
Gm2672,
Gm2679,
Gm1862,
Gm2685,
Gm2695,
Gm2698
|
12477932 |
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. Robert L Strausberg , Elise A Feingold , Lynette H Grouse , Jeffery G Derge , Richard D Klausner , Francis S Collins , Lukas Wagner , Carolyn M Shenmen , Gregory D Schuler , Stephen F Altschul , Barry Zeeberg , Kenneth H Buetow , Carl F Schaefer , Narayan K Bhat , Ralph F Hopkins , Heather Jordan , Troy Moore , Steve I Max , Jun Wang , Florence Hsieh , Luda Diatchenko , Kate Marusina , Andrew A Farmer , Gerald M Rubin , Ling Hong , Mark Stapleton , M Bento Soares , Maria F Bonaldo , Tom L Casavant , Todd E Scheetz , Michael J Brownstein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Christa Prange , Sam S Raha , Naomi A Loquellano , Garrick J Peters , Rick D Abramson , Sara J Mullahy , Stephanie A Bosak , Paul J McEwan , Kevin J McKernan , Joel A Malek , Preethi H Gunaratne , Stephen Richards , Kim C Worley , Sarah Hale , Angela M Garcia , Laura J Gay , Stephen W Hulyk , Debbie K Villalon , Donna M Muzny , Erica J Sodergren , Xiuhua Lu , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madan , Alice C Young , Yuriy Shevchenko , Gerard G Bouffard , Robert W Blakesley , Jeffrey W Touchman , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Martin I Krzywinski , Ursula Skalska , Duane E Smailus , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Marco A Marra , Mammalian Gene Collection Program Team |
2002-12-24 | - |
排名 | 科研单位 | 文献 |
---|---|---|
{{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
排名 | 研究人员 | 文献 |
---|---|---|
{{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员