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545030 Wdfy4

545030

Wdfy4

WD repeat and FYVE domain containing 4

protein-coding

Mus musculus

基因描述

Type Description
Definition WD repeat and FYVE domain containing 4

研究结论

Date Results Publications
2019-07-20 11:10:00 Genetic silencing of WDFY4 in B cells increased lipidation of LC3 independent of p62 and Beclin1, which are essential proteins of canonical autophagy. In vivo and in vitro data suggest that WDFY4 facilitates noncanonical autophagic activity. These findings provide a novel functional link underlying the mechanism of systemic lupus erythematosus in which WDFY4 influences B cell fate via noncanonical autophagy. 30257884
2019-05-11 13:16:00 Wdfy4 (-/-) mice failed to prime virus-specific CD8(+) T cells in vivo or induce tumor rejection, revealing a critical role for cross-presentation in antiviral and antitumor immunity. 30409884

名称对应

Type IDs
Synonymous Gm18810
Gene
UniProtKB-ID: WDFY4_MOUSE, E9PV60_MOUSE
UniprotKB: E9Q2M9, E9PV60
UniParc: UPI0001986444, UPI0003D72C90
EMBL: AC133585, AC165262, AC154206, AC154239
Ensembl: ENSMUSG00000051506
KO: mmu:545030
Nucleutide sequences
Ensembl_TRS: ENSMUST00000130509, ENSMUST00000061753
Protein sequencees
Ensembl_PRO: ENSMUSP00000117068, ENSMUSP00000057556
RefSeq: XP_006519340.1, XP_036014654.1, XP_006519341.1, XP_011243420.1, XP_006519342.1, XP_011243421.1, NP_001139494.1
Others
UniRef100: UniRef100_E9PV60, UniRef100_E9Q2M9
UniRef90: UniRef90_E9PV60, UniRef90_E9Q2M9
UniRef50: UniRef50_E9Q2M9
UniGene: Mm.318345

全选

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