| Type | Description |
|---|---|
| Definition | Mediterranean fever |
| Date | Results | Publications |
|---|---|---|
| 2021-04-17 13:17:00 | RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling. | 32989095 |
| 2019-11-09 10:28:00 | data show that TNF is a critical modulator of pyrin expression, inflammasome activation, and pyrin-inflammasomopathy. | 30457980 |
| 2018-04-28 11:55:00 | Pyrin (MEFV) is required for inflammasome activation and IL18 maturation, which promote intestinal barrier integrity and prevent colon inflammation and tumorigenesis. | 29203393 |
| 2017-08-26 11:36:00 | Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 and PRK2 to negatively regulate pyrin by phosphorylation. | 27569559 |
| 2013-06-01 10:02:00 | These results are consistent with a model in which pyrin acts to limit the release of IL-1beta generated by activation and assembly of inflammasomes in response to subclinical immune challenges. | 23226472 |
| Type | IDs |
|---|---|
| Synonymous | FMF, TRIM20, pyrin |
| Gene |
UniProtKB-ID:
MEFV_MOUSE,
Q32MT0_MOUSE,
Q32MT1_MOUSE
UniprotKB:
Q9JJ26,
Q32MT0,
Q32MT1
UniParc:
UPI0000021F2E,
UPI00005DC6EB,
UPI00005DC6EC
EMBL:
AF143409,
BC108994,
BC108993,
AC139347
Ensembl:
ENSMUSG00000022534
KO:
mmu:54483
|
| Nucleutide sequences |
EMBL-CDS:
AAF03766.1,
AAI08995.1,
AAI08994.1
Ensembl_TRS:
ENSMUST00000023180,
ENSMUST00000100222,
ENSMUST00000229725
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000023180,
ENSMUSP00000097795,
ENSMUSP00000154892
RefSeq:
NP_001155263.1,
NP_001155262.1,
XP_030105049.1,
XP_030105048.1,
XP_006522424.1,
NP_062326.2
|
| Others |
UniRef100:
UniRef100_Q32MT0,
UniRef100_Q32MT1,
UniRef100_Q9JJ26
UniRef90:
UniRef90_Q9JJ26
UniRef50:
UniRef50_Q9JJ26
UniGene:
Mm.143718
CCDS:
CCDS27907.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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