| Type | Description |
|---|---|
| Definition | 5'-3' exoribonuclease 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-03-28 12:47:00 | We show that knockdown of human XRN1, CNOT6 and ETF1 genes in HepG2 cells led to significant alteration in stability of specific mRNAs, alterations in half-life were inversely associated with transcription rates, mostly not resulting in changes in abundance | 31116665 |
| 2019-12-14 10:47:00 | Another decapping activator PatL1 directly interacts with CIR and alleviates the CIR-mediated inhibition of CCR4-NOT activity in vitro. Ribosome profiling revealed that XRN1 loss impacts not only on mRNA levels but also on the translational efficiency of many cellular transcripts likely as a consequence of incomplete decay | 31340047 |
| 2019-10-05 10:50:00 | This work provides insight into the role of the RNA decay factor Xrn1/XRN1 as a post-transcriptional regulator of autophagy. | 29465287 |
| 2018-12-01 11:36:00 | Authors use a series of assays to demonstrate that the 3'-terminal portion of the nucleocapsid (N) mRNA of Rift Valley fever virus can effectively stall and repress XRN1. The region responsible for impeding XRN1 includes a G-rich portion that likely forms a G-quadruplex structure. The 3'-terminal portions of ambisense-derived transcripts of multiple arenaviruses also stalled XRN1. | 29118186 |
| 2018-09-29 10:33:00 | Insertion of 5'-3' exoribonuclease 1 (XRN1)-resistant sequences (xrRNAs) into different reporter mRNAs allowed to monitor RNA decay activity by the nonsense-mediated mRNA decay pathway (NMD). | 27917860 |
| Type | IDs |
|---|---|
| Synonymous | SEP1 |
| Gene |
UniProtKB-ID:
XRN1_HUMAN
UniprotKB:
Q8IZH2
UniParc:
UPI000056D455,
UPI000020A388,
UPI0000074113
EMBL:
BC039314,
AL133623,
CR749518,
BX640905,
AK096177,
CR627396,
AY137776,
BC048104
Ensembl:
ENSG00000114127
KO:
hsa:54464
|
| Nucleutide sequences |
EMBL-CDS:
CAH10490.1,
AAN11306.1,
CAH18332.1,
AAH39314.1,
CAB63749.1,
BAC04718.1,
AAH48104.1,
CAE45950.1
Ensembl_TRS:
ENST00000463916,
ENST00000264951,
ENST00000392981
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000418404,
ENSP00000376707,
ENSP00000264951
RefSeq:
XP_016862129.1,
XP_016862131.1,
XP_016862130.1,
XP_011511221.1,
XP_006713736.1,
XP_011511224.1,
XP_011511222.1,
NP_061874.3,
NP_001269786.1,
NP_001269788.1
|
| Others |
UniRef100:
UniRef100_Q8IZH2
UniRef90:
UniRef90_Q8IZH2
UniRef50:
UniRef50_Q8IZH2
UniGene:
Hs.435103
CCDS:
CCDS63801.1,
CCDS75028.1,
CCDS3123.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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