| Type | Description |
|---|---|
| Definition | neuroligin 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-08-01 10:59:00 | We report gut symptoms in patients with the autism-associated R451C mutation encoding the neuroligin-3 protein. We show that many of the genes implicated in autism are expressed in mouse gut. The neuroligin-3 R451C mutation alters the enteric nervous system, causes gastrointestinal dysfunction, and disrupts gut microbe populations in mice. | 31119867 |
| 2020-03-14 12:11:00 | Our report of two missense variants affecting the normal localization of NLGN3 in a total of five affected individuals reinforces the involvement of the NLGN3 gene in a neurodevelopmental disorder characterized by ID and ASD. | 31184401 |
| 2020-01-18 10:24:00 | NLGN3 promoted neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway and providing a new target for neuroblastoma therapy | 31150649 |
| 2019-10-05 10:44:00 | the effects of rs1421589 within NRXN1, rs4844285 and rs11795613 within NLGN3, as well as rs5961397 within NLGX4X on Hirschsprung's disease phenotypes were also statistically significant. | 29622757 |
| 2018-12-22 10:18:00 | Wnt/beta-catenin signaling targets the trasncription of the autism-associated Neuroligin 3 gene. | 29503438 |
| Type | IDs |
|---|---|
| Synonymous | HNL3 |
| Gene |
UniProtKB-ID:
NLGN3_HUMAN,
X5D2P6_HUMAN,
X5D7L6_HUMAN,
X5DNV3_HUMAN,
Q4G160_HUMAN,
Q6MZK0_HUMAN,
B7Z3P8_HUMAN
UniprotKB:
Q9NZ94,
X5D2P6,
X5D7L6,
X5DNV3,
Q4G160,
Q6MZK0,
B7Z3P8
UniParc:
UPI0001914D1F,
UPI000006E386,
UPI000006FCBB,
UPI000056D3EC,
UPI00001BDB9F,
UPI0000212310
EMBL:
BC051715,
AF217413,
AK296217,
BC028738,
AF217411,
AF217412,
AB040913,
BX641059,
CH471132,
KJ534891,
KU178651,
KJ534889,
AL590764,
KJ534890,
AK074814,
GQ489207,
AK314699
Ensembl:
ENSG00000196338
KO:
hsa:54413
|
| Nucleutide sequences |
EMBL-CDS:
EAX05309.1,
AAF71233.1,
EAX05313.1,
EAX05310.1,
BAC11226.1,
EAX05307.1,
BAG37248.1,
EAX05312.1,
AAF71230.1,
AAF71232.1,
BAA96004.1,
AAF71231.1,
AAH51715.1,
EAX05308.1,
ADB12634.1,
ALQ34109.1,
AHW56529.1,
AHW56530.1,
AHW56531.1,
AAH28738.1,
CAE46030.1,
BAH12284.1
Ensembl_TRS:
ENST00000536169,
ENST00000358741,
ENST00000374051
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000363163,
ENSP00000351591,
ENSP00000445298
RefSeq:
NP_851820.1,
XP_016885086.1,
XP_011529276.1,
NP_001160132.1,
XP_006724726.1,
XP_006724725.2,
NP_061850.2,
NP_001308205.1
|
| Others |
UniRef100:
UniRef100_Q9NZ94,
UniRef100_Q9NZ94-2,
UniRef100_Q4G160,
UniRef100_Q6MZK0,
UniRef100_Q9NZ94-3
UniRef90:
UniRef90_Q62889-4,
UniRef90_A0A2K6P613,
UniRef90_Q9NZ94,
UniRef90_A0A452V896
UniRef50:
UniRef50_A0A1A8DLJ8,
UniRef50_A0A2K6P613,
UniRef50_Q62889-3
UniGene:
Hs.438877
CCDS:
CCDS55442.1,
CCDS55441.1,
CCDS14407.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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