| Type | Description |
|---|---|
| Definition | src family associated phosphoprotein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-20 13:26:00 | SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. | 32352382 |
| 2020-07-25 11:28:00 | These findings reveal that YopH prevents activation of both SKAP2-dependent and -independent neutrophilic defenses, uncouple integrin- and GPCR-dependent production from FcgammaR responses based on their SKAP2 dependency, and show that SKAP2 is not required for degranulation. | 32392230 |
| 2019-07-06 10:13:00 | SKAP2 depletion also disrupted actin cap and cortical granule-free domain formation, and arrested a large proportion of oocytes at the telophase stage. Moreover, Arp2/3 complex and WAVE2 expression was decreased after the depletion of SKAP2 activity. | 28933599 |
| 2017-08-19 12:34:00 | Skap2 is essential to activate the beta2 integrins, and loss of Skap2 function is sufficient to cause a leukocyte adhesion deficiency (LAD)-like phenotype in mice. | 28183734 |
| 2016-07-02 11:22:00 | Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs. | 26577701 |
| Type | IDs |
|---|---|
| Synonymous | 2610021A10Rik, AA960083, BB137539, RA70, SKAP-HOM, Saps, Scap2, mSKAP55R |
| Gene |
UniProtKB-ID:
SKAP2_MOUSE
UniprotKB:
Q3UND0
UniParc:
UPI0000026DB6,
UPI00000EB5EF
EMBL:
AK144289,
AB014485,
AK076000,
AF051324,
BC003711
Ensembl:
ENSMUSG00000059182
KO:
mmu:54353
|
| Nucleutide sequences |
EMBL-CDS:
AAC99297.1,
AAH03711.1,
BAE25817.1,
BAA77253.1,
BAC36111.1
Ensembl_TRS:
ENSMUST00000078214,
ENSMUST00000204778
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000077342,
ENSMUSP00000145462
RefSeq:
NP_061243.1
|
| Others |
UniRef100:
UniRef100_Q3UND0
UniRef90:
UniRef90_Q3UND0
UniRef50:
UniRef50_Q3UND0
UniGene:
Mm.221479,
Mm.392558
CCDS:
CCDS20137.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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