| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2 subunit alpha |
| Date | Results | Publications |
|---|---|---|
| 2018-11-10 12:20:00 | TorsinA was post-transcriptionally upregulated upon acute ER stress, suggesting a role in this response. Increased basal phosphorylation of eIF2alpha in DYT1 transgenic rats was associated with abnormal response to acute ER stress. Unbiased RNA-Seq-based transcriptomic analysis of embryonic brain tissue in heterozygous and homozygous DYT1 knockin mice confirmed presence of eIF2alpha dysregulation in the DYT1 brain. | 29289717 |
| 2017-07-22 10:09:00 | results demonstrate the sensitivity of eukaryotic initiation factor 2alpha-subunit (eIF2alpha) to stimulant exposure. Amphetamine possesses the ability to stimulate eIF2alpha phosphorylation in striatal and medial prefrontal cortex neurons in vivo in a dopamine D1 and D2 receptor-dependent manner. | 27338925 |
| 2016-04-02 11:21:00 | These results suggest a critical role of the mTOR/eIF2alpha pathway in hypoxic vascular remodeling and pulmonary arterial vascular smooth muscle cell proliferation of pulmonary hypertension. | 26120832 |
| 2014-09-27 12:05:00 | Dephosphorylation of eIF2alpha in the basolateral amygdala mediates memory reconsolidation of drug-paired stimuli. | 25057203 |
| 2014-05-31 11:09:00 | Data suggest maternal overweight due to high-fat diet up-regulates mTOR complex 1 (mechanistic target of rapamycin) activity and down-regulates eIF2 alpha subunit phosphorylation in placenta; such alterations contribute to placental/fetal overgrowth. | 24006279 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
IF2A_RAT
UniprotKB:
P68101
UniParc:
UPI0000001500
EMBL:
J02646,
BC087019
Ensembl:
ENSRNOG00000009432
KO:
rno:54318
|
| Nucleutide sequences |
EMBL-CDS:
AAA41110.1,
AAH87019.1
Ensembl_TRS:
ENSRNOT00000013375
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000013375
RefSeq:
NP_062229.1
|
| Others |
UniRef100:
UniRef100_Q6ZWX6
UniRef90:
UniRef90_Q6ZWX6
UniRef50:
UniRef50_Q6ZWX6
UniGene:
Rn.1488
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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