| Type | Description |
|---|---|
| Definition | eukaryotic translation initiation factor 2-alpha kinase 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:28:00 | Regulation of the cerebrovascular smooth muscle cell phenotype by mitochondrial oxidative injury and endoplasmic reticulum stress in simulated microgravity rats via the PERK-eIF2alpha-ATF4-CHOP pathway. | 32304741 |
| 2020-12-26 13:11:00 | Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. | 32251680 |
| 2020-06-20 12:12:00 | tudy reports, for the first time, that PKR-mediated harmful effects of PA in cultured cardiomyocytes via activation of JNK, NF-kB, and NLRP3 pathways. Inhibition of PKR is one of the possible mechanistic approaches to inhibit inflammation, oxidative stress, and apoptosis in lipotoxicity-induced cardiomyocyte damage. | 30259999 |
| 2017-10-14 11:58:00 | PKR plays a pivotal role in LPS-induced bone loss in periodontal disease. | 27718290 |
| 2016-10-22 11:24:00 | Increased levels of PKR and HMGB1 in synovium or blood appear to be involved in the occurrence and development ofrheumatoid arthritis (RA )in a rat model. Selective inhibition of PKR improves the symptoms of RA perhaps by inhibiting the release of HMGB1 | 26782432 |
| Type | IDs |
|---|---|
| Synonymous | Pkr, Prkr |
| Gene |
UniProtKB-ID:
E2AK2_RAT,
M0RDJ3_RAT
UniprotKB:
Q63184,
M0RDJ3
UniParc:
UPI00000E7962,
UPI000157E0C4
EMBL:
AABR07062641,
CH473947,
AABR07062642,
L29281,
AABR07062640
Ensembl:
ENSRNOG00000048315
KO:
rno:54287
|
| Nucleutide sequences |
EMBL-CDS:
AAA61926.1,
EDM02808.1
Gene_ORFName:
rCG_61784
Ensembl_TRS:
ENSRNOT00000072810,
ENSRNOT00000089185
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000067694,
ENSRNOP00000071646
RefSeq:
XP_008762647.1,
NP_062208.2,
XP_008762648.1
|
| Others |
UniRef100:
UniRef100_Q63184,
UniRef100_M0RDJ3
UniRef90:
UniRef90_Q63184
UniRef50:
UniRef50_P19525
UniGene:
Rn.10022
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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