| Type | Description |
|---|---|
| Definition | furin (paired basic amino acid cleaving enzyme) |
| Date | Results | Publications |
|---|---|---|
| 2020-07-04 12:44:00 | TGFbeta treatment aggravated hypoxia-induced BBB permeability but ALK5 or Furin blockade reversed injury-induced permeability changes. Thus during insult Furin compromises endothelial integrity by mediating the effects of TGFbeta. Targeting the Furin or ALK5 pathway may offer novel therapeutic strategies for improving BBB stability and CNS function during disease. | 31336100 |
| 2013-09-28 11:24:00 | overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner | 23686857 |
| 2013-08-10 11:47:00 | these data suggest that furin may play an important role in regulating apoptosis and proliferation of granulosa cells. | 23418414 |
| 2010-10-30 10:51:00 | upregulated during the preovulatory period, which results in activation of proteinases associated with the breakdown of the follicular wall during ovulation | 20375258 |
| 2010-08-30 11:59:00 | integrin bidirectional signalling is critically controlled by furin | 20076849 |
| Type | IDs |
|---|---|
| Synonymous | Pace, Pcsk3 |
| Gene |
UniProtKB-ID:
FURIN_RAT,
G3V7I9_RAT
UniprotKB:
P23377,
G3V7I9
UniParc:
UPI000019BC89,
UPI000012AD75
EMBL:
X55660,
CH473980,
AC114460
Ensembl:
ENSRNOG00000011352
KO:
rno:54281
|
| Nucleutide sequences |
EMBL-CDS:
CAA39193.1,
EDM08645.1,
EDM08646.1
Gene_ORFName:
rCG_24589
Ensembl_TRS:
ENSRNOT00000015521
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000015521
RefSeq:
XP_008757777.1,
XP_008757778.1,
NP_062204.2
|
| Others |
UniRef100:
UniRef100_P23377,
UniRef100_G3V7I9
UniRef90:
UniRef90_P23188
UniRef50:
UniRef50_P09958
UniGene:
Rn.3220
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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