| Type | Description |
|---|---|
| Definition | DNA polymerase delta 2, accessory subunit |
| Date | Results | Publications |
|---|---|---|
| 2021-01-09 13:33:00 | Polymerase delta promotes chromosomal rearrangements and imprecise double-strand break repair. | 33077594 |
| 2021-01-09 13:31:00 | ShRNA-based POLD2 expression knockdown sensitizes glioblastoma to DNA-Damaging therapeutics. | 31954770 |
| 2020-06-13 11:08:00 | In patients from 2 independent pedigrees, we have identified what we believe to be a novel syndrome with reduced functionality of the polymerase delta complex caused by germline biallelic mutations in POLD1 or POLD2 as the underlying etiology of a previously unknown autosomal-recessive syndrome that combines replicative stress, neurodevelopmental abnormalities, and immunodeficiency. | 31449058 |
| 2020-03-28 10:03:00 | The role in cellular processes (DNA replication, DNA repair, homologous recombination) and cell cycle regulation of 2 forms of human DNA polymerase delta: delta3 and delta4 was reviewed. (REVIEW) | 31326365 |
| 2017-10-28 11:24:00 | The proofreading activity of DNA polymerase delta plays a role in shunting DNA mismatch repair to an EXO1-dependent excision pathway as opposed to directly participating in gap formation via its 3'-5' exonuclease activity. | 28934474 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
DPOD2_HUMAN,
A0A087WWF6_HUMAN
UniprotKB:
P49005,
A0A087WWF6
UniParc:
UPI0002528875,
UPI000004D0E7
EMBL:
BC000459,
AC006454,
AF239710,
CH236960,
AY116646,
AK292347,
CH471128,
U21090,
AK312294
Ensembl:
ENSG00000106628
KO:
hsa:5425
|
| Nucleutide sequences |
EMBL-CDS:
EAL23767.1,
AAC50216.1,
AAH00459.1,
EAW61118.1,
AAM51148.1,
AAG09763.1,
BAF85036.1,
BAG35221.1
Ensembl_TRS:
ENST00000452185,
ENST00000406581,
ENST00000610533
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000395231,
ENSP00000386105,
ENSP00000480186
RefSeq:
XP_024302570.1,
NP_001120690.1,
NP_001243808.1,
NP_006221.3
|
| Others |
UniRef100:
UniRef100_P49005
UniRef90:
UniRef90_P49005
UniRef50:
UniRef50_P49005
UniGene:
Hs.306791,
Hs.740138
CCDS:
CCDS5477.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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