| Type | Description |
|---|---|
| Definition | poly(A) binding protein, nuclear 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-08 11:03:00 | We demonstrate that guanabenz acetate (GA) increases both the phosphorylation of the eukaryotic translation initiation factor 2alpha subunit and the splicing of Xbp1, key components of the UPR. Altogether these data show that modulation of protein folding regulation is beneficial for Oculopharyngeal muscular dystrophy (OPMD) and promote the further development of GA or its derivatives for treatment of OPMD in humans | 30649389 |
| 2020-01-11 10:21:00 | results from our study support a model where altered protein interactions with alanine-expanded PABPN1 that lead to loss or gain of function could contribute to pathology in oculopharyngeal muscular dystrophy | 30837270 |
| 2019-08-31 11:08:00 | Data show that a trans-acting factor, RNA binding protein HuR (HuR), which regulate poly(A) binding protein nuclear 1 (Pabpn1) expression specifically in mature muscle in vitro and in vivo. | 29939290 |
| 2018-03-31 10:49:00 | PABPN1-17A gave rise to: inhibition of Ca2+ release during ECC, depletion of sarcoplasmic reticulum Ca2+ content, reduced expression of ryanodine receptors, altered nuclear morphology and incapability to stimulate myoblast fusion. | 28303574 |
| 2017-11-11 13:09:00 | Matrin 3 (MATR3) is a novel protein interactor of PABPN1. MATR3 also binds and regulates the levels of long non-coding RNA (lncRNA) Neat1 and together with PABPN1 is required for normal paraspeckle function. | 28977530 |
| Type | IDs |
|---|---|
| Synonymous | PAB2, Pabp3, mPABII |
| Gene |
UniProtKB-ID:
PABP2_MOUSE
UniprotKB:
Q8CCS6
UniParc:
UPI0000021E34,
UPI00000E932C
EMBL:
U93050,
AK032172,
BC055866
Ensembl:
ENSMUSG00000022194
KO:
mmu:54196
|
| Nucleutide sequences |
EMBL-CDS:
AAH55866.1,
BAC27741.1,
AAC00210.1
Ensembl_TRS:
ENSMUST00000022808,
ENSMUST00000116476
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000112177,
ENSMUSP00000022808
RefSeq:
NP_062275.1
|
| Others |
UniRef100:
UniRef100_Q8CCS6
UniRef90:
UniRef90_Q8CCS6
UniRef50:
UniRef50_Q86U42
UniGene:
Mm.7723
CCDS:
CCDS27104.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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