| Type | Description |
|---|---|
| Definition | gamma-secretase activating protein |
| Date | Results | Publications |
|---|---|---|
| 2018-07-28 11:20:00 | These data demonstrate that GSAP proteins are differentially dysregulated in severe Alzheimer Disease, but only the full-length form was associated with cognitive test scores in Alzheimer Disease. | 28743126 |
| 2016-05-14 11:36:00 | GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease. | 26076991 |
| 2015-10-24 10:57:00 | Its promoter variant contributes to Alzheimer's disease liability. | 25037285 |
| 2013-04-06 12:21:00 | gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation | 23209290 |
| 2012-09-08 11:05:00 | Protocols for recombinant bacterial expression and purification of potentially important protein GSAP are not successful in generating soluble forms of GSAP that contain well-ordered and homogeneous tertiary structure. | 22681044 |
| Type | IDs |
|---|---|
| Synonymous | PION |
| Gene |
UniProtKB-ID:
GSAP_HUMAN
UniprotKB:
A4D1B5
UniParc:
UPI000019722C,
UPI0000237406,
UPI00004193AA,
UPI000015FEE3
EMBL:
AC004921,
CH236949,
CH471091,
AL834358,
BC101499,
AC073635,
AL079277,
AL079297
Ensembl:
ENSG00000186088
KO:
hsa:54103
|
| Nucleutide sequences |
EMBL-CDS:
CAD39023.2,
AAI01500.2,
EAL24199.1,
EAW77039.1,
CAB45193.1,
EAL24200.1,
CAB45152.1
Ensembl_TRS:
ENST00000257626
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000257626
RefSeq:
XP_011514627.1,
XP_016867840.1,
XP_011514634.1,
NP_001337829.1,
XP_011514632.1,
NP_001337826.1,
XP_016867835.1,
XP_016867837.1,
NP_001337825.1,
XP_011514629.1,
NP_059135.2,
NP_001337828.1,
NP_001337827.1,
XP_016867839.1,
XP_011514633.1,
XP_016867832.1,
NP_001337830.1,
XP_024302569.1
|
| Others |
UniRef100:
UniRef100_A4D1B5
UniRef90:
UniRef90_A4D1B5
UniRef50:
UniRef50_A4D1B5
UniGene:
Hs.186649
CCDS:
CCDS34672.2
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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