| Type | Description |
|---|---|
| Definition | neuronal guanine nucleotide exchange factor |
| Date | Results | Publications |
|---|---|---|
| 2019-05-25 12:04:00 | We found ephexin1 essential for the development of limb nerves toward their muscle targets, concluding that it functions as an intermediary to relay Eph signaling in this context | 29363583 |
| 2019-02-23 12:30:00 | These findings suggest that increased EphA4-ephexin1 signaling in the PFC plays a role in the pathophysiology of depression. | 28769056 |
| 2010-03-15 12:22:00 | An essential role is identified for rho guanine nucleotide exchange factor (RhoGEF) ephexin1 in the maturation of acetylcholine receptor clusters. | 20152127 |
| 2010-01-21 00:00:00 | FGFR-mediated phosphorylation of ephexin1 enhances the guanine nucleotide exchange activity toward RhoA without affecting the activity to Rac1 or Cdc42. | 17702745 |
| Type | IDs |
|---|---|
| Synonymous | Tims2, ephexin |
| Gene |
UniProtKB-ID:
NGEF_MOUSE,
E9QK62_MOUSE
UniprotKB:
Q8CHT1,
E9QK62
UniParc:
UPI00005645F0,
UPI00005645EF,
UPI00000E8D22
EMBL:
AJ238898,
AC102564,
BC039279,
BC022680,
AC157811,
AY038025
Ensembl:
ENSMUSG00000026259
KO:
mmu:53972
|
| Nucleutide sequences |
EMBL-CDS:
CAC00698.1,
AAH22680.1,
AAK71494.1,
AAH39279.1
Ensembl_TRS:
ENSMUST00000027477,
ENSMUST00000068681
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000027477,
ENSMUSP00000066894
RefSeq:
XP_036008310.1,
NP_063920.2,
XP_036008312.1,
NP_001104784.1
|
| Others |
UniRef100:
UniRef100_E9QK62,
UniRef100_Q8CHT1
UniRef90:
UniRef90_Q8CHT1
UniRef50:
UniRef50_Q8CHT1
UniGene:
Mm.435439
CCDS:
CCDS48307.1,
CCDS48306.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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