| Type | Description |
|---|---|
| Definition | caseinolytic mitochondrial matrix peptidase proteolytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:21:00 | Impaired Mitochondrial Stress Response due to CLPP Deletion Is Associated with Altered Mitochondrial Dynamics and Increased Apoptosis in Cumulus Cells. | 31939198 |
| 2019-10-12 10:47:00 | the CLPP is required for oocyte and embryo development and oocyte mitochondrial function and dynamics. Absence of CLPP results in mTOR pathway activation, and accelerated depletion of ovarian follicular reserve. | 29851234 |
| 2019-04-20 12:32:00 | Loss of the mitochondrial matrix protease CLPP results in a lean phenotype with improved glucose homeostasis. Whole-body CLPP-deficient mice are protected from diet-induced obesity and insulin resistance. CLPP ablation also leads to a decline in brown adipocytes function leaving mice unable to cope with a cold-induced stress due to non-functional adaptive thermogenesis. | 29588285 |
| 2019-02-09 12:13:00 | Our results show that absence of ClpP triggers compensatory responses in mice and suggest that ClpP might be dispensable for mammalian UPR(mt) initiation. Thus, we made an unexpected finding that deficiency of ClpP in mice is metabolically beneficial | 29420235 |
| 2017-08-19 10:08:00 | we demonstrate that a strong mitochondrial cardiomyopathy and diminished respiration due to DARS2 deficiency can be alleviated by the loss of CLPP, leading to an increased de novo synthesis of individual OXPHOS subunits. | 27154400 |
| Type | IDs |
|---|---|
| Synonymous | AU019820, D17Wsu160e |
| Gene |
UniProtKB-ID:
CLPP_MOUSE
UniprotKB:
O88696
UniParc:
UPI000000182B
EMBL:
AJ012250,
AK145765,
AJ012251,
AK168053,
AJ012253,
AK004024,
BC001998,
AJ012249,
AJ012252,
AJ005253
Ensembl:
ENSMUSG00000002660
KO:
mmu:53895
|
| Nucleutide sequences |
EMBL-CDS:
BAB23132.1,
CAA06443.1,
BAE40033.1,
CAA09966.1,
BAE26636.1,
AAH01998.1
Ensembl_TRS:
ENSMUST00000002735
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000002735
RefSeq:
NP_059089.1
|
| Others |
UniRef100:
UniRef100_O88696
UniRef90:
UniRef90_O88696
UniRef50:
UniRef50_O88696
UniGene:
Mm.287892
CCDS:
CCDS28920.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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