| Type | Description |
|---|---|
| Definition | peripheral myelin protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-01-16 15:58:00 | Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice. | 32265298 |
| 2020-05-02 10:49:00 | Peripheral myelin protein 2 - a novel cluster of mutations causing Charcot-Marie-Tooth neuropathy. | 31412900 |
| 2019-07-20 11:11:00 | High PMP2 expression is associated with melanoma cell invasion. | 30506895 |
| 2019-02-09 10:06:00 | These findings demonstrate that altered biophysical properties and functional dynamics of P2 may cause myelin defects in Charcot-Marie-Tooth disease 1 patients. | 28747762 |
| 2018-12-22 10:08:00 | The structural characterization of the F57A mutant of P2 which shows changes in the portal region and helix alpha2 and an unfolded status upon lipid bilayer binding. Further results suggest a central role for Phe57 in regulating the opening of the portal region in human P2, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2. | 29940944 |
| Type | IDs |
|---|---|
| Synonymous | CMT1G, FABP8, M-FABP, MP2, P2 |
| Gene |
UniProtKB-ID:
MYP2_HUMAN,
E5RH45_HUMAN
UniprotKB:
P02689,
E5RH45
UniParc:
UPI0001891FEC,
UPI000013CEEB
EMBL:
AC018616,
CH471068,
AK311758,
CR541649,
D16181,
X62167,
AH004648,
BC034997,
CR541738
Ensembl:
ENSG00000147588
KO:
hsa:5375
|
| Nucleutide sequences |
EMBL-CDS:
EAW87090.1,
AAH34997.1,
BAA03726.1,
CAG46538.1,
AAB32592.2,
CAG46450.1,
BAG34701.1,
CAA44096.1
Ensembl_TRS:
ENST00000256103,
ENST00000519260
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000256103,
ENSP00000429917
RefSeq:
NP_001335310.1,
NP_002668.1
|
| Others |
UniRef100:
UniRef100_P02689,
UniRef100_E5RH45
UniRef90:
UniRef90_P02689,
UniRef90_A0A2I3HCX6
UniRef50:
UniRef50_P04117,
UniRef50_A0A2I3HCX6
UniGene:
Hs.571512
CCDS:
CCDS6229.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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