| Type | Description |
|---|---|
| Definition | ADAM metallopeptidase domain 22 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-27 13:51:00 | ADAM22/LGI1 complex as a new actionable target for breast cancer brain metastasis. | 33208158 |
| 2018-12-22 10:47:00 | the LGI1-ADAM22 complex functions as the trans-synaptic machinery for precise synaptic transmission | 29670100 |
| 2018-11-03 11:44:00 | ADAM22 is critically involved in miR-449a-reduced tamoxifen resistance of estrogen receptor-positive breast cancer cells as a direct target of miR-449a. | 30278449 |
| 2017-05-13 11:55:00 | these results support the existence of a second mechanism, alternative to inhibition of protein secretion, by which ADLTE-causing LGI1 mutations exert their loss-of-function effect extracellularly, and suggest that interactions of LGI1 with both ADAM22 and ADAM23 play an important role in the molecular mechanisms leading to utosomal dominant lateral temporal epilepsy | 27760137 |
| 2014-01-11 10:06:00 | Disruption of LGI1-ADAM22 interaction reduces synaptic AMPA receptors in hippocampal neurons. | 24227725 |
| Type | IDs |
|---|---|
| Synonymous | ADAM 22, EIEE61, MDC2 |
| Gene |
UniProtKB-ID:
ADA22_HUMAN,
Q08AL8_HUMAN
UniprotKB:
Q9P0K1,
Q08AL8
UniParc:
UPI000013FC58,
UPI000016981A,
UPI000002A34E,
UPI000002A34F,
UPI00001254DC,
UPI000002A350
EMBL:
AF155382,
AB009671,
AF155381,
AF073291,
AK291010,
AC005075,
AF158637,
BC125118
Ensembl:
ENSG00000008277
KO:
hsa:53616
|
| Nucleutide sequences |
EMBL-CDS:
AAF73288.1,
BAA32350.1,
AAD55251.1,
BAA32349.1,
AAF22476.2,
AAF73289.1,
BAF83699.1,
AAI25119.1
Ensembl_TRS:
ENST00000398209,
ENST00000398204,
ENST00000398201,
ENST00000265727
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000381267,
ENSP00000381262,
ENSP00000265727,
ENSP00000381260
RefSeq:
XP_011514622.1,
NP_001311346.1,
XP_016867818.1,
XP_011514626.1,
XP_016867828.1,
XP_016867824.1,
XP_011514623.1,
XP_016867829.1,
NP_001311350.1,
NP_001311348.1,
XP_011514620.1,
NP_001311347.1,
XP_016867825.1,
XP_016867822.1,
NP_068369.1,
NP_004185.1,
XP_016867819.1,
NP_068368.2,
XP_016867830.1,
XP_005250502.1,
NP_068367.1,
XP_016867820.1,
XP_011514625.1,
XP_006716091.1,
XP_011514624.1,
XP_016867823.1,
XP_016867827.1,
XP_016867826.1,
NP_057435.2,
NP_001311349.1,
XP_016867821.1,
XP_011514621.1,
XP_006716092.1
|
| Others |
UniRef100:
UniRef100_Q9P0K1,
UniRef100_Q08AL8
UniRef90:
UniRef90_Q9P0K1,
UniRef90_Q9P0K1-4
UniRef50:
UniRef50_Q9R1V6
UniGene:
Hs.256398
CCDS:
CCDS43608.1,
CCDS43609.1,
CCDS43610.1,
CCDS47637.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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