| Type | Description |
|---|---|
| Definition | Glutamate-cysteine ligase catalytic subunit |
| Date | Results | Publications |
|---|---|---|
| 2018-07-21 11:52:00 | we report phenotypic analysis of a complete loss-of-function mutant in the gamma-glutamylcysteine synthetase catalytic subunit (Gclc) gene in the fruit fly Drosophila melanogaster.Gclc encodes the evolutionarily conserved catalytic component of the enzyme that conjugates glutamate and cysteine in the GSH biosynthesis pathway. | 29021278 |
| 2012-11-17 11:32:00 | Microarray analysis revealed that glutamate cysteine ligasec overexpression and thus enhanced glutathione production has a broad impact on gene expression that largely affects different processes in young and old flies. | 22579812 |
| 2010-01-21 00:00:00 | The reversibility of the dephosphorylation-dependent activation was indicated by the time-dependent inactivation of the in vitro activated Drosophila GCL, by preincubation with MgATP. | 16324789 |
| 2010-01-21 00:00:00 | Neuronal overexpression of GCLc in a long-lived background extended mean and maximum life spans up to 50%, without affecting the rate of oxygen consumption by the flies | 16148000 |
| 2010-01-21 00:00:00 | investigation of mutations in GCL modifier subunit and the GCL catalytic subunit that modify catalytic activity and lower glutathione levels | 12954617 |
| Type | IDs |
|---|---|
| Synonymous | 2259, CG2259, DmGCLC, DmGCS, DmGCSh, Dmel\CG2259, GCL, GCLC, GCLc, GCSh, GclC, Gcs, Gcsh, gclc |
| Gene |
UniProtKB-ID:
GSH1_DROME,
A4V448_DROME
UniprotKB:
Q9W3K5,
A4V448
UniParc:
UPI0000124D76
EMBL:
AY071586,
AF244351,
AE014298
EnsemblGenome:
FBgn0040319
KO:
dme:Dmel_CG2259
|
| Nucleutide sequences |
EMBL-CDS:
AAF66980.1,
AAF46321.1,
AAL49208.1,
AHN59473.1,
AAS65282.1,
AHN59472.1
Gene_ORFName:
CG2259,
CG2259,
Dmel_CG2259
EnsemblGenome_TRS:
FBtr0071107,
FBtr0340138,
FBtr0071108,
FBtr0340139,
FBtr0340138,
FBtr0071108,
FBtr0071107,
FBtr0340139
|
| Protein sequencees |
EnsemblGenome_PRO:
FBpp0071063,
FBpp0309124,
FBpp0309125,
FBpp0089361,
FBpp0089361,
FBpp0071063,
FBpp0309124,
FBpp0309125
RefSeq:
NP_525005.2,
NP_001285001.1,
NP_996373.1,
NP_001285002.1
|
| Others |
UniRef100:
UniRef100_Q9W3K5
UniRef90:
UniRef90_Q9W3K5
UniRef50:
UniRef50_Q9W3K5
UniGene:
Dm.1723
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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