| Type | Description |
|---|---|
| Definition | protein phosphatase 1, regulatory subunit 3C |
| Date | Results | Publications |
|---|---|---|
| 2020-02-22 11:01:00 | Metformin-activated AMPK decreases hepatic PPP1R3C expression, leading to the suppression of hepatic gluconeogenesis through blocking cAMP-stimulated TORC2 dephosphorylation | 31181215 |
| 2014-11-08 13:38:00 | metabolic crosstalk is due to decreased mTORC1 and SREBP activity in PTG knockout mice or knockdown cells, suggesting a positive feedback loop in which once accumulated, glycogen stimulates the mTORC1/SREBP1 pathway to shift energy storage to lipogenesis. | 24722244 |
| 2014-06-21 13:12:00 | removing PTG, a glycogen synthesis activator protein, nearly completely eliminates Lafora bodies and rescues the neurodegeneration, myoclonus,seizure susceptibility, and behavioral abnormality. | 24419970 |
| 2011-08-20 10:49:00 | Laforin-deficient mice lacking PTG have greatly decreased Lafora bodies and normal glycogen levels. | 21552327 |
| 2010-01-21 00:00:00 | These data indicate that disruption of PTG expression resulted in the uncoupling of PP1 activity from glycogen metabolizing enzymes, the enhancement of glycogenolysis, and a dramatic decrease in cellular glycogen levels. | 16354703 |
| Type | IDs |
|---|---|
| Synonymous | PTG, Ppp1r5 |
| Gene |
UniProtKB-ID:
PPR3C_MOUSE
UniprotKB:
Q7TMB3
UniParc:
UPI000019C77A
EMBL:
AK078506,
BC054739,
BC052769,
U89924
Ensembl:
ENSMUSG00000067279
KO:
mmu:53412
|
| Nucleutide sequences |
EMBL-CDS:
AAB49689.1,
AAH54739.1,
BAC37313.1,
AAH52769.1
Ensembl_TRS:
ENSMUST00000087321
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000084578
RefSeq:
NP_058550.1
|
| Others |
UniRef100:
UniRef100_Q7TMB3
UniRef90:
UniRef90_Q7TMB3
UniRef50:
UniRef50_Q7TMB3
UniGene:
Mm.24724
CCDS:
CCDS37968.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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