| Type | Description |
|---|---|
| Definition | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-29 10:47:00 | Study in APC and/or gankyrin-deficient mice revealed that gankyrin in epithelial cell contributes to the development of sporadic colorectal cancer by reducing the expression of c-Myc, a critical mediator of the APC signaling pathway, and interleukin-6. | 30513515 |
| 2019-07-06 10:47:00 | These studies show that Gank protein promotes hepatocyte proliferation by elimination of tumor-suppressor proteins. | 30109252 |
| 2013-09-21 12:39:00 | the present study clarified, at least partly, mechanisms of vascular tumorigenesis, and suggests that gankyrin might play a physiological role in hypoxic responses besides its roles as an oncoprotein. | 23376718 |
| 2013-04-27 11:19:00 | FXR prevents liver cancer by inhibiting the gankyrin promoter via C/EBPbeta-HDAC1 complexes, leading to subsequent protection of tumor suppressor proteins from degradation. | 23172628 |
| 2010-09-06 12:20:00 | Gankyrin is a key regulator of Ras-mediated activation of Akt through inhibition of the downstream RhoA/ROCK pathway and thus plays an essential role in Ras-induced tumorigenesis. | 20628200 |
| Type | IDs |
|---|---|
| Synonymous | AW554874 |
| Gene |
UniProtKB-ID:
PSD10_MOUSE,
A2AG83_MOUSE
UniprotKB:
Q9Z2X2,
A2AG83
UniParc:
UPI0000023792,
UPI00001F859B
EMBL:
BC026931,
AK009068,
AL672306,
BC056196,
AB022022,
AK018233,
AK136400,
CH466616
Ensembl:
ENSMUSG00000116430,
ENSMUSG00000031429
KO:
mmu:53380
|
| Nucleutide sequences |
EMBL-CDS:
EDL23939.1,
AAH56196.1,
BAA36969.1,
BAB31128.1,
AAH26931.1,
BAB26053.1,
BAE22964.1
Ensembl_TRS:
ENSMUST00000230246,
ENSMUST00000033805,
ENSMUST00000112978
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000033805,
ENSMUSP00000155318,
ENSMUSP00000108602
RefSeq:
NP_058579.2,
NP_001157649.1
|
| Others |
UniRef100:
UniRef100_Q9Z2X2,
UniRef100_A2AG83
UniRef90:
UniRef90_Q9Z2X2,
UniRef90_A0A2K6JR09
UniRef50:
UniRef50_Q9Z2X2,
UniRef50_A0A2I3H4E8
UniGene:
Mm.17640
CCDS:
CCDS30444.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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