| Type | Description |
|---|---|
| Definition | two pore segment channel 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-20 12:51:00 | TPC1 is involved in the norepinephrine (NE)-stimulated [Ca(2+)]i rise in Smooth muscle cells. Inhibition of TPC1 activity by NED 19 could be the reason for partial inhibition of aortic rings contraction in response to NE. | 31557916 |
| 2020-04-25 10:40:00 | cryo-EM structure of human TPC2 provides insights into the mechanism of PI(3,5)P2-regulated gating of TPC2, which is distinct from that of TPC1 | 30860481 |
| 2018-11-10 11:35:00 | These data point to a process in which Ca(2+) permeation in human TPC1 has a positive feedback on channel activity while Na(+) acts as a negative regulator. | 28252105 |
| 2018-06-23 10:47:00 | a cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth transmembrane region (S4) but to a cytosolic downstream region (S4-S5 linker). | 29129203 |
| 2017-05-20 14:34:00 | These findings indicate potential differential regulation of signaling processes by TPC1 and TPC2 in breast cancer cells. | 27353380 |
| Type | IDs |
|---|---|
| Synonymous | TPC1 |
| Gene |
UniProtKB-ID:
TPC1_HUMAN,
B3KSG7_HUMAN,
B7Z3R2_HUMAN
UniprotKB:
Q9ULQ1,
B3KSG7,
B7Z3R2
UniParc:
UPI00004066FB,
UPI00003727B8,
UPI000006D7A1,
UPI0000041252,
UPI0000036165
EMBL:
AC127004,
BC152423,
AK093490,
AK075071,
AB032995,
BC136795,
BC136796,
AC089999,
AK296268,
AK057414,
AY083666,
AC010178,
BC150203
Ensembl:
ENSG00000186815
KO:
hsa:53373
|
| Nucleutide sequences |
EMBL-CDS:
AAM01199.1,
AAI50204.1,
AAI52424.1,
AAI36796.1,
AAI36797.1,
BAA86483.2,
BAC11385.1,
BAG52729.1,
BAH12298.1
Ensembl_TRS:
ENST00000335509,
ENST00000541517,
ENST00000550785,
ENST00000392569
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000438125,
ENSP00000335300,
ENSP00000448083,
ENSP00000376350
RefSeq:
NP_001288143.1,
XP_011536794.1,
XP_011536792.1,
NP_001338276.1,
XP_016874969.1,
NP_001137291.1,
XP_016874971.1,
NP_001338275.1,
NP_060371.2,
XP_011536795.1
|
| Others |
UniRef100:
UniRef100_B3KSG7,
UniRef100_Q9ULQ1
UniRef90:
UniRef90_Q9ULQ1
UniRef50:
UniRef50_Q9ULQ1
UniGene:
Hs.524763
CCDS:
CCDS31908.1,
CCDS44985.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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