| Type | Description |
|---|---|
| Definition | phospholipase C gamma 2 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:29:00 | Novel BCL2 mutations in venetoclax-resistant, ibrutinib-resistant CLL patients with BTK/PLCG2 mutations. | 32232486 |
| 2020-12-26 13:13:00 | Noncatalytic Bruton's tyrosine kinase activates PLCgamma2 variants mediating ibrutinib resistance in human chronic lymphocytic leukemia cells. | 32184360 |
| 2020-11-21 13:22:00 | Alzheimer's-associated PLCgamma2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. | 32514138 |
| 2020-07-25 11:49:00 | The effect of the PLCG2 rs72824905-G on 7 neurodegenerative diseases and longevity, was studied in 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. It was associated with reduced Alzheimer disease, Lewy-body dementia, and frontotemporal dementia. It had no effect on Parkinson disease, amyotrophic lateral sclerosis or multiple sclerosis. It was also associated with longevity. | 31131421 |
| 2020-01-11 10:52:00 | We performed pathway analyses on the largest available collection of advanced age-related macular cases and controls in the world. Eight genes strongly contributed to significant pathways from the three larger databases, and one gene (PLCG2) was central to significant pathways from all four databases. This is, to our knowledge, the first study to identify PLCG2 as a candidate gene for AMD based solely on genetic burden. | 31560769 |
| Type | IDs |
|---|---|
| Synonymous | APLAID, FCAS3, PLC-IV, PLC-gamma-2 |
| Gene |
UniProtKB-ID:
PLCG2_HUMAN
UniprotKB:
P16885
UniParc:
UPI00001411F7
EMBL:
BC014561,
AC092142,
BC011772,
X14034,
AY364256,
CH471114,
BC018646,
BC007565,
M37238,
AB208914,
AC098966,
AC099524
Ensembl:
ENSG00000197943
KO:
hsa:5336
|
| Nucleutide sequences |
EMBL-CDS:
BAD92151.1,
AAH07565.1,
AAQ76815.1,
AAH18646.1,
AAA60112.1,
CAA32194.1,
EAW95524.1,
EAW95525.1,
AAH11772.1,
AAH14561.1
Ensembl_TRS:
ENST00000564138
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000482457
RefSeq:
NP_002652.2
|
| Others |
UniRef100:
UniRef100_P16885
UniRef90:
UniRef90_P16885
UniRef50:
UniRef50_P16885
UniGene:
Hs.413111
CCDS:
CCDS42204.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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