| Type | Description |
|---|---|
| Definition | SHC adaptor protein 3 |
| Date | Results | Publications |
|---|---|---|
| 2021-03-13 13:17:00 | The Shc protein Rai enhances T-cell survival under hypoxia. | 31944299 |
| 2019-05-25 11:21:00 | our results indicate the importance of Shc3 in HCC progression and identify Shc3 as a novel biomarker and potential therapeutic target in HCC.Significance: Ectopic expression of Shc3 forms a complex with MVP/MEK/ERK to potentiate ERK activation and plays an important role in sorafinib resistance in HCC. | 29330146 |
| 2019-02-23 11:14:00 | We may conclude that RAI plays an important role in hypoxic signaling in Neuroblastoma (NB)cells and the interplay between RAI and HIF-1alpha may be relevant in the protection of NB cells against hypoxia. Our results may contribute to a further understanding the physiology of NB cells and the molecular mechanisms involved in their survival, with important implications in NB progression | 29057481 |
| 2015-10-17 11:53:00 | High SHC3 expression is associated with glioblastoma. | 25062668 |
| 2012-08-04 11:17:00 | Rai (ShcC/N-Shc), a member of the family of Shc-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells. | 22311806 |
| Type | IDs |
|---|---|
| Synonymous | N-Shc, NSHC, RAI, SHCC |
| Gene |
UniProtKB-ID:
SHC3_HUMAN
UniprotKB:
Q92529
UniParc:
UPI000034E5D0,
UPI0000073E1F
EMBL:
BC026314,
AL353150,
D84361,
AL160054
Ensembl:
ENSG00000148082
KO:
hsa:53358
|
| Nucleutide sequences |
EMBL-CDS:
AAH26314.1,
BAA12322.1,
BAA12323.1
Ensembl_TRS:
ENST00000375835
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000364995
RefSeq:
NP_058544.3,
XP_016870298.1,
XP_011517087.1,
XP_011517088.1,
XP_016870299.1
|
| Others |
UniRef100:
UniRef100_Q92529
UniRef90:
UniRef90_Q92529
UniRef50:
UniRef50_Q92529
UniGene:
Hs.292737
CCDS:
CCDS6681.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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