| Type | Description |
|---|---|
| Definition | ubiquitin associated and SH3 domain containing A |
| Date | Results | Publications |
|---|---|---|
| 2020-05-30 11:52:00 | Upon TCR engagement, UBASH3A enhances the downmodulation of cell-surface TCR-CD3. | 31659016 |
| 2020-04-04 10:28:00 | observations suggested that the dysregulation of UBASH3A might be associated with the pathogenesis of rheumatoid arthritis (RA), and UBASH3A gene polymorphisms (rs1893592 and rs3788013) might contribute to RA susceptibility in Chinese Han population. | 30822156 |
| 2019-02-23 11:07:00 | this reduction in UBASH3A, as a consequence of the minor allele at rs1893592, resulted in increased secretion of IL-2, a key cytokine that is required for T-cell activation and function but is deficient in some type 1 diabetes (T1D). Our study provides new mechanistic insights into how rs1893592 affects T1D and autoimmunity and how interactions between multiple T1D-associated, noncoding variants influence the disease risk | 29491471 |
| 2018-02-10 10:24:00 | UBASH3A gene SNP is associated with susceptibility to atopic dermatitis in Chinese Han population. | 28747736 |
| 2017-09-02 10:26:00 | UBASH3A attenuates the NF-kappaB signal transduction upon T-cell receptor (TCR) stimulation by specifically suppressing the activation of the IkappaB kinase complex. UBASH3A interacts with TAK1 and NEMO, suggesting that UBASH3A regulates the NF-kappaB signaling pathway by an ubiquitin-dependent mechanism. T1D risk alleles at rs11203203 and rs80054410 increase UBASH3A expression in CD4(+) T cells upon TCR stimulation. | 28607106 |
| Type | IDs |
|---|---|
| Synonymous | CLIP4, STS-2, TULA, TULA-1 |
| Gene |
UniProtKB-ID:
UBS3A_HUMAN
UniprotKB:
P57075
UniParc:
UPI0000E5A3ED,
UPI000002B674,
UPI0000137941
EMBL:
BC069511,
BC069483,
CH471079,
AF520809,
BC069357,
AF521702,
AJ277750,
BC069577,
AP001746
Ensembl:
ENSG00000160185
KO:
hsa:53347
|
| Nucleutide sequences |
EMBL-CDS:
AAH69357.1,
AAP80731.1,
AAP80738.1,
EAX09560.1,
AAH69483.1,
AAH69511.1,
CAB91543.1
Ensembl_TRS:
ENST00000291535,
ENST00000398367,
ENST00000319294
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000317327,
ENSP00000291535,
ENSP00000381408
RefSeq:
XP_011527911.1,
NP_001230396.1,
XP_011527908.1,
XP_011527912.1,
XP_006724076.1,
NP_001001895.1,
XP_011527907.1,
XP_011527909.1,
NP_061834.1
|
| Others |
UniRef100:
UniRef100_P57075
UniRef90:
UniRef90_P57075
UniRef50:
UniRef50_P57075
UniGene:
Hs.473912
CCDS:
CCDS33566.1,
CCDS58791.1,
CCDS13687.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员