| Type | Description |
|---|---|
| Definition | progesterone receptor membrane component 1 |
| Date | Results | Publications |
|---|---|---|
| 2020-02-15 11:58:00 | Pgrmc1 may exert neuroprotective effects by blocking Tnf-alpha induction of downstream gene targets including gbp4, ifit3, and rtp4. In addition, Pgrmc1 may alter neuroinflammation by regulating neurosteroid synthesis, both directly through steroidogenic enzyme activation and indirectly through Nr4a1 regulation of steroidogenic enzyme expression. | 31026287 |
| 2019-11-23 12:49:00 | Loss of Pgrmc1 increased mature SREBP-1 protein level, suggesting that induction of hepatic steatosis in Pgrmc1 KO mice might be triggered by de novo lipogenesis. Moreover, Pgrmc1 KO mice were also more vulnerable to early stage of non-alcoholic steatohepatitis, showing high levels of alanine aminotransferase, obesity-linked pro-inflammatory cytokines, and fibrosis markers. | 30356113 |
| 2019-05-04 10:43:00 | survival of adult primordial ovarian follicles dependent in part on progesterone receptor membrane component 1 and 2 | 30306772 |
| 2018-05-12 11:27:00 | These results indicated that PGRMC1 mediated progesterone-induced suppression of oocyte meiotic progression and primordial folliculogenesis by decreasing intra-oocyte cAMP levels. | 27848973 |
| 2017-10-14 12:15:00 | The current studies establish the presence of PGRMC1 in retina and lay the foundation for analysis of its biological function. | 26642738 |
| Type | IDs |
|---|---|
| Synonymous | AA415812, HPR6.6, PPMR, Vema, mPR |
| Gene |
UniProtKB-ID:
PGRC1_MOUSE,
Q3TXU8_MOUSE
UniprotKB:
O55022,
Q3TXU8
UniParc:
UPI0000020F69
EMBL:
AK168882,
AK166240,
AK162315,
AK167655,
AK159101,
AF042491,
BC006016,
AK153272,
AK159599,
AK159345
Ensembl:
ENSMUSG00000006373
KO:
mmu:53328
|
| Nucleutide sequences |
EMBL-CDS:
AAB97466.1,
AAH06016.1,
BAE39706.1,
BAE31859.1,
BAE34817.1,
BAE38654.1,
BAE35007.1,
BAE40700.1,
BAE36850.1,
BAE35219.1
Ensembl_TRS:
ENSMUST00000073339
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000073061
RefSeq:
NP_058063.2
|
| Others |
UniRef100:
UniRef100_O55022
UniRef90:
UniRef90_P70580
UniRef50:
UniRef50_O00264
UniGene:
Mm.9052
CCDS:
CCDS30060.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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